Coordinate expression of alkali and DTNB myosin light chains during transformation of rabbit fast muscle by chronic stimulation
Coordinate expression of alkali and DTNB myosin light chains during transformation of rabbit fast muscle by chronic stimulation
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慢性刺激兔快肌转化过程中碱和DTNB肌球蛋白轻链的协调表达
DOI：
10.1016/0014-5793(83)80605-x
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发表时间：
1983
期刊：
影响因子：
3.5
通讯作者：
D. Pette
中科院分区：
文献类型：
--
作者：
K. Seedorf;U. Seedorf;D. Pette
慢性神经刺激导致快肌球蛋白轻链(LC)Lc1f和Lc2f几乎完全交换为慢轻链Lc1s和Lc2s。Lc3f仅下降了30%。DTNB LCS(LC2f至LC2s)的更换先于LC1f至LC1s。然而，总碱与总DTNB LCS的等摩尔比保持不变。这指向了一种迄今未知的调节，它保持了这一比例，而无论碱性和DTNB LC是以快或慢的同种类型表达的。
Chronic nerve stimulation induces an almost complete exchange of the fast myosin light chains (LC) LC1f and LC2f to the slow light chains LC1s and LC2s. LC3f decreases only by 30%. The exchange of the DTNB LCs (LC2f to LC2s) precedes that of LC1f to LC1s. However, the equimolar ratio of total alkali to total DTNB LCs is maintained. This points to a hitherto unknown regulation that preserves this ratio independent of whether alkali and DTNB LCs are expressed in fast or slow isotypes.