High serum magnesium is associated with lower risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease.
High serum magnesium is associated with lower risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease.
复制标题
高血清镁与非酒精性脂肪肝患者患肝细胞癌的风险较低相关。
作者：
Yu,Yi-Chuan;Paragomi,Pedram;Wang,Renwei;Liang,Feiran;Luu,HungN;Behari,Jaideep;Yuan,Jian-Min
背景非酒精性脂肪性肝病（NAFLD）是肝细胞癌（HCC）发病率上升的主要原因。镁是细胞活动中的主要阳离子。有关镁水平及其与肝癌关系的流行病学数据很少。本研究旨在研究NAFLD患者血清镁水平与HCC风险之间的相关性。从2004年到2018年，匹兹堡大学医学中心电子健康记录中共确定了26，053例NAFLD患者。经过平均5.15年的随访，395名患者在首次测量血清镁后发生了HCC。采用考克斯比例风险回归模型计算校正年龄、性别、种族、体重指数、利尿剂使用、2型糖尿病史、高血压史、高脂血症史、结果发生HCC的NAFLD患者的平均（±标准差）血清镁（0.769 ± 0.131 mmol/L）高于无HCC患者（0.789 ± 0.125 mmol/L;p= 0.003）。与最低四分位数相比，肝癌患者血清镁第二、第三和第四分位数的HR（95%CI）分别为0.87（0.67-1.12）、0.77（0.57-1.04）和0.73（0.56-0.96），调整多个潜在混杂因素后结论NAFLD患者血清镁水平升高与肝癌风险降低显著相关。
BackgroundNonalcoholic fatty liver disease (NAFLD) is a major contributor to the rising incidence of hepatocellular carcinoma (HCC). Magnesium is a major cation in cellular activities. Epidemiological data on magnesium level and its relation to HCC are sparse. This study aimed to examine the associations between serum levels of magnesium and the risk of HCC among patients with NAFLD.MethodsA total of 26,053 patients with NAFLD were identified in the University of Pittsburgh Medical Center Electronic Health Records from 2004 through 2018. After an average of 5.15 years of follow‐up, 395 patients developed HCC after the first measurement of serum magnesium. Cox proportional hazards regression model was used to calculate hazard ratios (HRs) and 95% CIs of HCC incidence associated with quartile levels of serum magnesium after adjustment for age, sex, race, body mass index, diuretics use, history of type 2 diabetes, history of hypertension, history of hyperlipidemia, and tobacco smoking.ResultsPatients with NAFLD who developed HCC had a significantly lower mean (± standard deviation) serum magnesium (0.769 ± 0.131 mmol/L) than those who remained free of HCC (0.789 ± 0.125 mmol/L;p= .003). Compared with the lowest quartile, the HRs (95% CIs) of HCC second, third, and fourth quartiles of serum magnesium were 0.87 (0.67–1.12), 0.77 (0.57–1.04), and 0.73 (0.56–0.96), respectively, after adjustment for multiple potential confounders (Ptrend= .02).ConclusionThis finding suggests higher levels of serum magnesium were significantly associated with decreased risk of HCC among patients with NAFLD.