Human evoked brain potentials and alcohol.
Human evoked brain potentials and alcohol.
复制标题
人类诱发大脑电位和酒精。
DOI：
10.1111/j.1530-0277.1981.tb04904.x
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Begleiter,H
中科院分区：
文献类型：
--
作者：
Porjesz,B;Begleiter,H
近年来，已广泛认识到慢性酒精中毒者普遍存在脑损伤和/或功能障碍（Begleiter和Platz，1972;兰金，1975）。随着计算机断层扫描（CT扫描）的出现，对慢性酒精中毒者脑中结构损伤的评估已大大便利，表明皮质沟加宽（罗恩，1978; Cala等人，1978; Cala，1979; Bergman，1979;威尔金森和Carlen，1980; Begleiter等人，1980年b）。然而，这种技术目前是有限的，因为它允许更好地可视化一些大脑部位，（例如，大脑皮层）在排除其他（例如，脑干）。结构损伤和脑功能水平之间的关系仍然很脆弱（罗恩等人，1978;威尔金森和Carlen，1980; Lusins等人，1980年）。神经心理学测试虽然有助于评估慢性酗酒者的认知缺陷，但由于它们必须完全依赖于行为，因此受到限制;由于大脑位点和行为功能之间的关系脆弱，很难从行为缺陷中推断出病理过程。此外，相同的行为缺陷可能很好地反映了不同复杂神经生理过程的产物。诱发电位（EP）或事件相关电位（ERP）技术提供了一种独特的方法来评估大脑功能的水平，因为它允许同时调查电生理和认知。EP技术包括在每次重复呈现任何形式的简短感觉刺激后立即记录大脑的电反应，并使用信号平均技术提取时间锁定的诱发活动。神经电活动就是时间-
N recent years it has become widely recog-I nized that brain damage and/or dysfunction is prevalent in chronic alcoholics (Begleiter & Platz, 1972; Rankin, 1975). With the advent of the computerized tomography scan (CT scan), the assessment of structural damage in the brains of chronic alcoholics has been greatly facilitated, indicating widened cortical sulci (Ron, 1978; Cala et al., 1978; Cala, 1979; Bergman, 1979; Wilkinson and Carlen, 1980; Begleiter et al., 1980b). However, this technique is presently limited as it permits better visualization of some brain loci,(eg, cerebral cortex) at the exclusion of others (eg, brain stem). The relationship between structural damage and level of brain functioning remains tenuous (Ron et al., 1978; Wilkinson and Carlen, 1980; Lusins et al., 1980). Neuropsychological tests, although helpful in assessing cognitive deficits in chronic alcoholics, are limited in that they must rely solely on behavior; because of the tenuous relationship between brain loci and behavioral functions, it is difficult to infer pathological processes from behavioral deficits. Furthermore, the same behavioral deficits may well reflect the product of different complex neurophysiological processes. The evoked potential (EP) or event-related potential (ERP) technique offers a unique approach for assessing level of brain functioning as it permits the simultaneous investigation of electrophysiology and cognition. The EP technique consists of recording the electrical response of the brain immediately following each repeated presentation of a brief, sensory stimulus of any modality, and using signal averaging techniques to extract the time-locked evoked activity. The neuroelectric activity that is time-