Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation
Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation
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DOI：
10.1002/cncr.23116
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发表时间：
2007-12-25
影响因子：
3.4
通讯作者：
Alexander, Erik K.
中科院分区：
文献类型：
--
作者：
Yassa, Leila;Cibas, Edmund S.;Alexander, Erik K.
背景。甲状腺结节患者的诊断评估不精确。尽管细针抽吸 (FNA) 有诸多好处，但大多数因细胞学异常而转诊接受手术的患者被证明患有良性疾病。最近的技术和程序进展表明，这一缺点可以得到缓解，尽管很少有数据证实在未经选择的患者中存在这种益处。方法。 10 年间，共有 2587 名连续患者接受了甲状腺超声评估，并接受了超声引导下 FNA (UG-FNA)，对所有测量值≥1 cm 的甲状腺结节进行了超声引导 FNA (UG-FNA)。抽吸细胞学结果与组织学结果相关。确定了所有患者和接受手术的患者中甲状腺癌的患病率。计算手术风险。结果。 14% 的患者存在测量值 >= 1 厘米的肿瘤： 43% 的患者患有测量值大于等于 1 厘米的肿瘤
BACKGROUND. The diagnostic evaluation of patients with thyroid nodules is imprecise. Despite the benefits of fine-needle aspiration (FNA), most patients who are referred for surgery because of abnormal cytology prove to have benign disease. Recent technologic and procedural advances suggest that this shortcoming can be mitigated, although few data confirm this benefit in unselected patients.METHODS. A total of 2587 sequential patients were evaluated by thyroid ultrasound and were offered ultrasound-guided FNA (UG-FNA) of all thyroid nodules that measured >= 1 cm during a 10-year period. Results of aspiration cytology were correlated with histologic findings. The prevalence of thyroid cancer in all patients and in those who underwent surgery was determined. Surgical risk was calculated.RESULTS. Tumors that measured >= 1 cm were present in 14% of patients: Forty-three percent of patients had tumors that measured