Comparative Expression Analysis of the Neurogenins in Xenopus tropicalis and Xenopus laevis
Comparative Expression Analysis of the Neurogenins in Xenopus tropicalis and Xenopus laevis
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DOI：
10.1002/dvdy.21845
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发表时间：
2009-02-01
影响因子：
2.5
通讯作者：
Henningfeld, Kristine A.
中科院分区：
文献类型：
--
作者：
Nieber, Frank;Pieler, Tomas;Henningfeld, Kristine A.
神经原素（Ngn 1-3）家族是脊椎动物神经发生的关键调控因子。在发育中的脊椎动物神经系统中，Ngns对神经元命运的承诺和参与神经元细胞类型身份的规范至关重要。非洲爪蟾（Xenopus laevis）被广泛用作研究脊椎动物神经发生早期事件的模型系统，然而，只有与哺乳动物Ngn2关系最密切的Ngnr-1被描述和表征。目前，我们比较分析了Ngn1-3在热带田鼠和野田鼠胚胎中的表达。爪蟾Ngns存在于从原肠动物阶段开始的重叠和独特的神经系统区域，这表明这个重要的转录因子家族在两栖动物神经系统的建立中具有不同的作用。科学通报，2009(8):451-458。(c) 2009 Wiley-Liss, Inc。
The Neurogenin (Ngn 1-3) family of proneural basic helix-loop-helix (bHLH) transcription factors are key regulators of vertebrate neurogenesis. In the developing vertebrate nervous system, the Ngns are essential for the commitment to a neuronal fate and participate in the specification of neuronal cell-type identity. Xenopus laevis is widely used as a model system to study the early events of vertebrate neurogenesis, however, only Ngnr-1, which is most closely related to the mammalian Ngn2, has been described and characterized. Presently, we describe a comparative expression analysis of the Ngn1-3 in X. tropicalis and X. laevis embryos. The Xenopus Ngns are present in overlapping, as well as unique regions of the nervous system starting at gastrula stages, suggesting distinct roles for this important family of transcriptional factors in the establishment of the amphibian nervous system. Developmental Dynamics 238:451-458, 2009. (c) 2009 Wiley-Liss, Inc.