BROMINATED TYROSINE-DERIVED METABOLITES FROM THE SPONGE IANTHELLA-BASTA
BROMINATED TYROSINE-DERIVED METABOLITES FROM THE SPONGE IANTHELLA-BASTA
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DOI：
10.1071/ch9810765
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发表时间：
1981-01-01
影响因子：
1.1
通讯作者：
BLOUNT, JF
中科院分区：
文献类型：
--
作者：
KAZLAUSKAS, R;LIDGARD, RO;BLOUNT, JF
从海绵I中分离出新的代谢物[77]，每种代谢物均源自4个溴酪氨酸单位。够了Bastadin-1（2）、bastadin-2（3）和bastadin-3（4）是由单一的酚氧化偶联得到的; bastadin-4（5）、bastadin-5（6）、bastadin-6（8）和bastadin-7（7）是由2个酚氧化偶联反应形成的大环化合物。化合物（2）-（8）对革兰氏阳性菌具有较强的体外抗菌活性。
Novel metabolites [77], each originating from 4 bromotyrosine units, were isolated from the sponge I. basta. Bastadin-1 (2), bastadin-2 (3) and bastadin-3 (4) are derived from a single phenol oxidative coupling; the macrocyclic compounds bastadin-4 (5), bastadin-5 (6), bastadin-6 (8) and bastadin-7 (7) are formed by 2 phenol oxidative coupling reactions. Compounds (2)-(8) showed potent in vitro antimicrobial activity against Gram-positive organisms.