Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy
Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy
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DOI：
10.1080/01635581.2015.1082110
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发表时间：
2015-11-17
影响因子：
2.9
通讯作者：
Ramirez de Molina, Ana
中科院分区：
文献类型：
--
作者：
Gonzalez-Vallinas, Margarita;Reglero, Guillermo;Ramirez de Molina, Ana
癌症仍然是当今死亡的一个重要原因，因此，仍然需要新的治疗方法。迷迭香(Rosmarinus officinalsL.)已有报道在体外和动物实验中都具有抗肿瘤活性。其中一些活性归因于其主要成分，如鼠尾草酸、鼠尾草醇、熊果酸和迷迭香酸。最初，迷迭香的抗肿瘤作用归因于其抗氧化活性。然而，近年来有关迷迭香的抗氧化作用和抗肿瘤作用之间缺乏相关性的报道，其抗肿瘤作用的分子机制也不尽相同。此外，在美国食品和药物管理局和欧洲食品和安全局的支持下，迷迭香提取物的特定成分被证明对人类健康是安全的，并被用作食品中的抗氧化剂，这表明这种制剂可能很容易作为癌症治疗的补充方法使用。本文就迷迭香的抗癌作用、与其相关的分子机制以及迷迭香与现有抗癌药物的相互作用进行综述。通过对迷迭香提取物与其分离成分的比较，探讨了迷迭香提取物作为癌症治疗辅助剂的可能性。
Cancer remains an important cause of mortality nowadays and, therefore, new therapeutic approaches are still needed. Rosemary (Rosmarinus officinalis L.) has been reported to possess antitumor activities both in vitro and in animal studies. Some of these activities were attributed to its major components, such as carnosic acid, carnosol, ursolic acid, and rosmarinic acid. Initially, the antitumor effects of rosemary were attributed to its antioxidant activity. However, in recent years, a lack of correlation between antioxidant and antitumor effects exerted by rosemary was reported, and different molecular mechanisms were related to its tumor inhibitory properties. Moreover, supported by the U.S. Food and Drug Administration and the European Food and Safety Authority, specific compositions of rosemary extract were demonstrated to be safe for human health and used as antioxidant additive in foods, suggesting the potential easy application of this agent as a complementary approach in cancer therapy. In this review, we aim to summarize the reported anticancer effects of rosemary, the demonstrated molecular mechanisms related to these effects and the interactions between rosemary and currently used anticancer agents. The possibility of using rosemary extract as a complementary agent in cancer therapy in comparison with its isolated components is discussed.