Coevolution between bacterial CRISPR-Cas systems and their bacteriophages.
Coevolution between bacterial CRISPR-Cas systems and their bacteriophages.
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DOI：
10.1016/j.chom.2021.03.018
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发表时间：
2021-05
影响因子：
30.3
通讯作者：
B. N. Watson;Jurre A. Steens;Raymond H. J. Staals;E. Westra;S. van Houte
中科院分区：
文献类型：
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作者：
B. N. Watson;Jurre A. Steens;Raymond H. J. Staals;E. Westra;S. van Houte
CRISPR-Cas系统为细菌和古细菌提供了针对其病毒（噬菌体和噬菌体）和其他寄生遗传因子的适应性遗传免疫力。CRISPR-Cas系统是高度多样化的，我们才刚刚开始了解它们在噬菌体防御中的相对重要性。在这篇综述中，我们将讨论CRISPR-Cas针对噬菌体的免疫进化的时间和原因，以及这反过来如何选择噬菌体免疫逃避的进化。最后，我们将讨论我们目前对是否以及何时观察到CRISPR-Cas系统与噬菌体之间的共同进化的理解，以及CRISPR-Cas免疫机制如何影响这一点。
CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity against their viruses (bacteriophages and phages) and other parasitic genetic elements. CRISPR-Cas systems are highly diverse, and we are only beginning to understand their relative importance in phage defense. In this review, we will discuss when and why CRISPR-Cas immunity against phages evolves, and how this, in turn, selects for the evolution of immune evasion by phages. Finally, we will discuss our current understanding of if, and when, we observe coevolution between CRISPR-Cas systems and phages, and how this may be influenced by the mechanism of CRISPR-Cas immunity.