Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy.
Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy.
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癌症治疗中的靶向DNA修复和染色质串扰。
DOI：
10.3390/cancers13030381
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发表时间：
2021-01-20
期刊：
影响因子：
5.2
通讯作者：
Bhaskara S
中科院分区：
文献类型：
--
作者：
Johnson DP;Chandrasekharan MB;Dutreix M;Bhaskara S
除了转录和复制外，靶向癌症中的异常DNA修复是癌症研究人员感兴趣的领域。在癌细胞中选择性地抑制DNA修复可导致细胞毒性或细胞抑制作用，并克服染色体易位或突变所带来的生存优势。在这篇综述中，我们强调了DNA修复相关事件在发育性疾病和癌症中的相关性，并讨论了克服这些参与不同细胞过程的事件的机制。发育性疾病和癌症背后的异常DNA修复途径是治疗干预的潜在目标。针对DNA修复信号效应器，调节剂和检查点蛋白，并利用合成致死现象导致了开创性的发现。目前正在努力将基本发现有效地转化为临床。染色质调节是DNA修复级联的一个组成部分，也是一个新兴的研究领域。在这里，我们讨论了DNA修复疗法取得的一些关键进展，以及在各种细胞过程中染色质和修复途径之间的串扰，重点是癌症。
Targeting aberrant DNA repair in cancers in addition to transcription and replication is an area of interest for cancer researchers. Inhibition of DNA repair selectively in cancer cells leads to cytotoxic or cytostatic effects and overcomes survival advantages imparted by chromosomal translocations or mutations. In this review, we highlight the relevance of DNA repair-linked events in developmental diseases and cancers and also discuss mechanisms to overcome these events that participate in different cellular processes. Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.
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影响因子：
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