Defective cold-induced stimulation of thyroxine 5'-deiodinase in brown adipose tissue of the genetically obese (ob/ob) mouse.
Defective cold-induced stimulation of thyroxine 5'-deiodinase in brown adipose tissue of the genetically obese (ob/ob) mouse.
复制标题
在遗传性肥胖 (ob/ob) 小鼠的棕色脂肪组织中，寒冷诱导的甲状腺素 5-脱碘酶刺激缺陷。
DOI：
10.1016/0006-291x(85)90400-0
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
J. Himms‐Hagen
中科院分区：
文献类型：
--
作者：
A. Kates;J. Himms‐Hagen
一只正常的瘦小鼠暴露在寒冷(14℃)下12小时，棕色脂肪组织中甲状腺激素5‘-脱碘酶的活性增加了26倍。相比之下，遗传肥胖的肥胖小鼠暴露在寒冷中只会导致甲状腺激素5‘-脱碘酶活性增加一倍多一点。棕色脂肪组织内源性3，5，3‘-三碘甲腺原氨酸的生理意义尚不清楚。然而，有缺陷的冷诱导刺激肥胖小鼠棕色脂肪组织中的5‘-脱碘酶似乎可能导致该组织处于相对的甲状腺功能低下状态。众所周知，甲状腺激素是棕色脂肪组织对去甲肾上腺素做出正常生热反应所必需的。提示肥胖小鼠5‘-脱碘酶反应缺陷可能与棕色脂肪组织对冷暴露和去甲肾上腺素的生热反应缺陷有关。
Exposure of a normal lean mouse to cold (14° C) for 12 h increases the activity of thyroxine 5′-deiodinase in brown adipose tissue 26-fold. In contrast, exposure of the genetically obese, ob ob, mouse to cold results in little more than a doubling of thyroxine 5′-deiodinase activity. The physiological significance of endogenous 3, 5, 3′-triiodothyronine production in brown adipose tissue is not understood. However, it seems likely that defective cold-induced stimulation of the 5′-deiodinase in brown adipose tissue of the ob ob mouse might cause a relatively hypothyroid state of the tissue. Thyroid hormone is known to be required for a normal thermogenic response of brown adipose tissue to noradrenaline. It is suggested that the defect in the response of the 5′-deiodinase in the ob ob mouse could contribute to the defective thermogenic response of brown adipose tissue to cold-exposure and to noradrenaline.