No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death.
No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death.
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Apoε4 等位基因、HIV 感染、年龄、神经心理学结果或死亡之间没有关联。
DOI：
10.1007/s13365-014-0290-2
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发表时间：
2015-02
影响因子：
3.2
通讯作者：
Sacktor N
中科院分区：
文献类型：
--
作者：
Becker JT;Martinson JJ;Penugonda S;Kingsley L;Molsberry S;Reynolds S;Aronow A;Goodkin K;Levine A;Martin E;Miller EN;Munro CA;Ragin A;Sacktor N
ApoE基因的ε4等位基因可能与HIV疾病个体的身体健康和认知功能有重要的相互作用。本研究的目的是在一个大的，充分表征的研究样本中检查ε4，HIV疾病，年龄，神经心理损伤和死亡之间的关系。参与多中心艾滋病队列研究的2，846名男性有ApoE基因分型和神经心理学测试数据可供分析。我们发现艾滋病毒感染与死亡时间（任何原因）以及年龄，种族和教育之间存在显着关联。但是，ApoE状态与死亡时间无显著相关性。同样，我们发现HIV感染与发生认知损害的时间以及年龄、教育和HIV血清状态之间存在显著相关性; Apoε4状态与发生认知损害无关。ApoE、HIV感染和年龄对认知功能损害无显著交互作用。这些数据重复并加强了先前的发现，即ApoE ε4与HIV疾病的认知结果之间缺乏相关性。我们的结论是，在一项仅限男性的研究中，大多数参与者的年龄小于65岁（范围：22-87岁），这似乎是合理的结论，ε4等位基因与HIV血清状态没有显着相互作用。
The ε4 allele of the ApoE gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment and death in a large, well-characterized study sample. 2,846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment, as well as age, education, and HIV serostatus; Apoε4 status was not related to incident cognitive impairment. There were no significant interactions between ApoE, HIV infection, and age on cognitive impairment. These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and cognitive outcomes in HIV disease. We conclude that within the specific constraints of an exclusively male study in which the majority of participants were less than 65 years of age (range: 22-87 years), it appears reasonable to conclude that the ε4 allele is not significantly interacting with HIV serostatus.