Proton irradiation of [O-18]O-2: Production of [F-18]F-2 and [F-18]F-2+[F-18]OF2
Proton irradiation of [O-18]O-2: Production of [F-18]F-2 and [F-18]F-2+[F-18]OF2
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DOI：
10.1016/0969-8051(95)02037-3
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发表时间：
1996-04-01
影响因子：
3.1
通讯作者：
Barrio, JR
中科院分区：
文献类型：
--
作者：
Bishop, A;Satyamurthy, N;Barrio, JR
本文研究了用O-18(p，n)F-18反应在铝、铜、镀金铜和镍制成的直孔或锥形小体积靶体中制备F-18亲电试剂的方法。采用单步、两步和改进的两步三种照射方案恢复F-18的活性。单步照射方案在所有靶体中进行了测试。基于一步法性能，铝靶被广泛应用于两步法和改进的两步法辐照方案的研究中，使用11 MeV回旋加速器和两步法辐照方案，从铝靶体内可重复地回收>；1Ci[F-18]F-2，根据臭氧生成量和靶气体中存在的氮杂质，分别提出了一步法和改进的两步法靶中OF2和FONO2(硝酸氟)形成的可能的自由基机理。
The production of F-18 electrophilic reagents via the O-18(p,n)F-18 reaction has been investigated in small-volume target bodies made of aluminum, copper, gold plated copper and nickel, having straight or conical bore shapes. Three irradiation protocols-single-step, two-step and modified two-step-were used for the recovery of the F-18 activity. The single-step irradiation protocol was tested in all the target bodies. Based on the single step performance, aluminum targets were utilized extensively in the investigation of the two step and modified two-step irradiation protocols, With an 11-MeV cyclotron and using the two-step irradiation protocol, >1Ci [F-18]F-2 was recovered reproducibly from an aluminum target body, Probable radical mechanisms for the formation of OF2 and FONO2 (fluorine nitrate) in the single-step and modified two step targets are proposed based on the amount of ozone generated and the nitrogen impurity present in the target gases, respectively.