Parkinson's disease in patients with Alzheimer's disease.
Parkinson's disease in patients with Alzheimer's disease.
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阿尔茨海默病患者的帕金森病。
DOI：
10.1001/archneur.1986.00520070020010
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发表时间：
1986
影响因子：
--
通讯作者：
Sumi Sm
中科院分区：
文献类型：
--
作者：
J. Leverenz;Sumi Sm
由于阿尔茨海默病患者常出现帕金森病的临床表现，我们对40例经病理证实的阿尔茨海默病患者的黑质进行了帕金森病的改变（神经元丢失、路易体或神经原纤维缠结）的检查。十八名患者的黑质有一种或多种这些变化。随后，我们回顾了他们的临床记录，发现 13 名患者出现强直（伴或不伴震颤），9 名患者二次诊断为可能或明确的帕金森病。其中11名（85%）患者存在帕金森病的病理改变。这些发现表明，大多数有锥体外系体征的阿尔茨海默病患者黑质有帕金森病的病理改变。
Because patients with Alzheimer's disease often develop clinical manifestations of Parkinson's disease, we examined the substantia nigra in 40 cases of pathologically confirmed Alzheimer's disease for the changes of Parkinson's disease (neuronal loss, Lewy bodies, or neurofibrillary tangles). Eighteen patients had one or more of these changes in the substantia nigra. Subsequently, we reviewed their clinical records and found that rigidity, with or without tremor, had been noted in 13 patients, and nine patients had a second diagnosis of possible or definite Parkinson's disease. Eleven (85%) of these patients had the pathologic changes of Parkinson's disease. These findings suggest that the majority of patients with Alzheimer's disease with extrapyramidal signs have the pathologic changes of Parkinson's disease in the substantia nigra.