Understanding the effect of magnesium degradation on drug release and anti-proliferation on smooth muscle cells for magnesium-based drug eluting stents
Understanding the effect of magnesium degradation on drug release and anti-proliferation on smooth muscle cells for magnesium-based drug eluting stents
复制标题
了解镁降解对镁基药物洗脱支架药物释放和抗平滑肌细胞增殖的影响
DOI：
10.1016/j.corsci.2017.04.016
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发表时间：
2017-07-15
影响因子：
8.3
通讯作者：
Yuan, Guangyin
中科院分区：
文献类型：
--
作者：
Shi, Yongjuan;Pei, Jia;Yuan, Guangyin
为了了解基质降解对镁合金药物洗脱支架载药系统的可能影响，在Mg-d-Zn-Zr支架上制备了雷帕霉素载药聚（乳酸-羟基乙酸）涂层，用于在磷酸盐缓冲体系中的系统研究。镁的降解显著加速了药物的释放动力学，这主要归因于扩散控制阶段的H-2释放，而此后的PLGA侵蚀。虽然释放的雷帕霉素的理化稳定性部分恶化镁降解，镁基板上的载药系统表现出更有效的长期抑制平滑肌细胞增殖在体外相比，载药不锈钢。
To understand the possible influence of substrate degradation on the drug-loading system of magnesium alloy-based drug-eluting stents, a rapamycin drug-loading poly(lactic-co-glycolic acid) coating was prepared on Mg-d-Zn-Zr stents for a systematic investigation in a phosphate buffer system. Mg degradation accelerated the drug release kinetics prominently, which was mainly attributed to H-2 evolution in the diffusion-controlled phase while thereafter to PLGA erosion. Although physiochemical stability of the released rapamycin was partially deteriorated by magnesium degradation, the drug-loading system on magnesium substrates exhibited a more potent long-term inhibition on smooth muscle cell proliferation in vitro as compared to drug-loaded stainless steel.