Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
复制标题
炎症反应导致 COVID-19 患者死后大脑皮层神经元死亡
DOI：
10.1021/acschemneuro.1c00111
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发表时间：
2021-06-08
影响因子：
5
通讯作者：
Aliaghaei, Abbas
中科院分区：
文献类型：
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作者：
Boroujeni, Mahdi Eskandarian;Simani, Leila;Aliaghaei, Abbas
最近的2019冠状病毒病（COVID-19）大流行对全球人民产生了不利影响。越来越多的文献表明，COVID-19感染会导致神经系统并发症和表现。在此，我们探索了严重COVID-19患者死后大脑皮层的炎症和免疫反应。参与者包括三名于2020年3月26日至2020年4月17日诊断为严重COVID-19的患者和三名对照患者。我们的研究结果表明，COVID-19组中反应性星形胶质细胞和活化小胶质细胞数量激增，谷胱甘肽沿着水平降低，炎症和免疫相关基因11、113、1 L 6、IFITM、mxi和OAS 2上调。总的来说，这些数据意味着氧化应激可能引起丝状介导的神经炎症，最终导致COVID-19患者大脑皮层中的神经元细胞死亡。
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes 11,113, 1L6, IFITM, mxi, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a filial-mediated neuroinflarntnation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.