Androgens and estrogens modulate 5-HT1A and 5-HT1B agonist effects on aggression.
Androgens and estrogens modulate 5-HT1A and 5-HT1B agonist effects on aggression.
复制标题
雄激素和雌激素调节 5-HT1A 和 5-HT1B 激动剂对攻击性的影响。
DOI：
10.1016/s0031-9384(98)00240-6
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发表时间：
1999
影响因子：
2.9
通讯作者：
Lu,S
中科院分区：
文献类型：
--
作者：
Cologer-Clifford,A;Simon,NG;Richter,ML;Smoluk,SA;Lu,S
柯洛克利福德，a . n. g.西蒙，m. l.里克特，s.斯莫鲁克和s.卢。雄激素和雌激素调节5- ht1a和5- ht1bagists对攻击的影响。中国生物医学工程学报，2009(4):823-828。-雄性间的攻击性行为是由性腺类固醇促进的，并被5-羟色胺（5-HT）抑制，可能是通过其在5- ht1a和5- ht1b受体位点的作用。为了研究这些神经内分泌和神经化学调节系统之间的相互作用，对CF-1雄性小鼠进行了性腺切除术，并植入含有二乙基己烯雌酚（DES，一种合成雌激素）、非芳构化雄激素甲基三烯醇酮（R1881）或二氢睾酮（DHT）或睾酮(T)的硅胶胶囊。2周后，给予8-羟基-2-（二正丙胺）四氢萘林（8-OH-DPAT， 5- ht1拮抗剂，0.1或1.0 mg/kg）、CGS12066B （5- ht1拮抗剂，4.0或8.0 mg/kg）、0.1或1.0 mg/kg 8-OH-DPAT + 4.0 mg/kg CGS12066B或载具，并进行攻击检测。在DES存在的情况下，与对照相比，较高的8-OH-DPAT剂量与CGS联合给予的攻击减弱。当给予非芳香化雄激素（R1881或DHT）时，除0.1 mg/kg 8-OH-DPAT外，所有药物治疗均显著降低了攻击行为。在提供雌激素和雄激素刺激的T存在的情况下，8-OH-DPAT或CGS12066B高剂量组和1.0 mg/kg 8-OH-DPAT + CGS12066B组的攻击得分显著降低。对运动行为变化的评估显示，在所有激素条件下给药8.0 mg/kg CGS12066B时，运动行为显著受损，表明这些治疗组的攻击性行为减少是非特异性的。结果表明，甾体环境对5- ht1a和5-HT1Bagonists调节攻击行为的能力有不同的影响，雌激素产生的环境比雄激素对5-羟色胺能抑制男性典型攻击行为的限制性更强。
COLOGER-CLIFFORD, A., N. G. SIMON, M. L. RICHTER, S. SMOLUK AND S. LU. Androgens and estrogens modulate 5-HT1Aand 5-HT1Bagonist effects on aggression. PHYSIOL BEHAV 65(4/5) 823–828, 1999.—Intermale offensive aggressive behavior is facilitated by gonadal steroids and inhibited by serotonin (5-HT), presumably through its effects at 5-HT1Aand 5-HT1Breceptor sites. To examine the interaction between these neuroendocrine and neurochemical regulatory systems, CF-1 male mice were gonadectomized and implanted with silastic capsules containing either diethylstilbestrol (DES, a synthetic estrogen), the nonaromatizable androgens methyltrienolone (R1881) or dihydrotestosterone (DHT), or testosterone (T). Two weeks later, they were given 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1Aagonist; 0.1 or 1.0 mg/kg), CGS12066B (a 5-HT1Bagonist; 4.0 or 8.0 mg/kg), 0.1 or 1.0 mg/kg 8-OH-DPAT + 4.0 mg/kg CGS12066B, or vehicle, and tested for aggression. In the presence of DES, the higher 8-OH-DPAT dose given in combination with CGS attenuated aggression in comparison to vehicle controls. When given nonaromatizable androgen (R1881 or DHT), all drug treatments except 0.1 mg/kg 8-OH-DPAT significantly reduced offensive attack behavior. In the presence of T, which provides estrogenic and androgenic stimulation, aggression scores were significantly reduced when males were given the high dose of 8-OH-DPAT or CGS12066B, as well as in the 1.0 mg/kg 8-OH-DPAT + CGS12066B condition. Assessments of changes in motor behavior showed significant impairment when 8.0 mg/kg CGS12066B was administered across all hormonal conditions, indicating that reductions in offensive aggression in these treatment groups were nonspecific. The results demonstrate differential effects of the steroidal environment on the ability of 5-HT1Aand 5-HT1Bagonists to modulate aggression, with estrogens producing a more restrictive environment than androgens for serotonergic inhibition of male-typical aggressive behavior.