Recent advances in renal phosphate transport
Recent advances in renal phosphate transport
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DOI：
10.1111/j.1744-9987.2005.00290.x
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发表时间：
2005-08-01
影响因子：
1.9
通讯作者：
Murer, H
中科院分区：
文献类型：
--
作者：
Hernando, N;Biber, J;Murer, H
磷酸盐（P-i）稳态是通过调节肠道吸收和肾脏排泄来实现的。 P-i 的肾近端重吸收是通过控制近端小管刷状缘膜中 NaPi-IIa 协同转运蛋白的量来调节的。因此，需要了解控制 NaPi-IIa 顶端表达的分子机制，才能全面了解磷酸盐平衡是如何发生的。在这篇综述中，我们将总结我们目前关于该转运蛋白家族的顶端表达和膜修复调节机制的知识。
Phosphate (P-i) homeostasis is achieved by adjusting the intestinal absorption and the renal excretion. Renal proximal reabsorption of P-i is regulated by controlling the amount of NaPi-Ila cotransporters in the brush border membrane of proximal tubules. Therefore, the understanding of the molecular mechanisms that control the apical expression of NaPi-Ila is required to have a full picture of how phosphate balancing takes place. In this review we will summarize our present knowledge about the mechanisms involved in the regulation of the apical expression and membrane retrieval of this family of transporters.