Red blood cell membrane dynamics in schizophrenia. I. Membrane fluidity.
Red blood cell membrane dynamics in schizophrenia. I. Membrane fluidity.
复制标题
精神分裂症的红细胞膜动力学。
DOI：
10.1016/0920-9964(94)90014-0
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发表时间：
1994
影响因子：
4.5
通讯作者：
vanKammen,DP
中科院分区：
文献类型：
--
作者：
Yao,JK;vanKammen,DP
采用荧光探针DPH（1,6-二苯基-1,3,5-己三烯），测定了氟哌啶醇停药前（n=26）和停药后（n=16）以及年龄和性别匹配的正常对照（n=22）的红细胞鬼膜稳态各向异性（rs）值。氟哌啶醇治疗的患者以5 - 20mg /天的剂量治疗至少5周。无药物患者平均36天不服用任何精神药物。氟哌啶醇治疗组的平均值（0.2422−0.0076）与未用药组的平均值（0.2445−0.0092）和正常对照组的平均值（0.2383−0.0083）无显著差异。然而，与对照组相比，在无药物的精神分裂症患者中观察到显著增加（p=0.037）。无药复发患者的平均值显著高于氟哌啶醇治疗组（p<0.05）。无药物患者的值的变化与其精神病评分的增加也显著相关（r=0.74,p=0.001）。然而，红细胞鬼膜的“结构顺序”与年龄、发病年龄、每日氟哌啶醇剂量、血浆氟哌啶醇水平、血浆胆固醇浓度、病程、氟哌啶醇治疗或无药期无关。因此，目前的数据表明，氟哌啶醇治疗不影响红细胞膜流动性。然而，在氟哌啶醇停药后，那些RBC膜流动性下降的患者可能在6周内复发，这与精神病的增加有关。
Using the fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene), steady-state anisotropy (rs) values were determined in red blood cell (RBC) ghost membranes of schizophrenic patients before (n=26) and after (n=16) haloperidol withdrawal, and age- and sex-matched normal controls (n=22). Patients on haloperidol were treated with doses between 5 and 20 mg/day for at least 5 weeks. Drug-free patients had been free of all psychotropic medication for an average of 36 days. The meanrsvalue of haloperidol-treated patients (0.2422−0.0076) was not significantly different from that of either the drug-free patients (0.2445−0.0092) or the normal controls (0.2383−0.0083). A significant increase (p=0.037) inrsvalues, however, was observed in the drug-free schizophrenic patients as compared to that of the controls. Furthermore, the meanrsvalues of relapsed drug-free patients were significantly (p<0.05) higher than in the same individuals on haloperidol treatment. Changes inrsvalues of drug-free patients were also significantly correlated with their increase in psychosis ratings (r=0.74,p=0.001). The ‘structural order’ of RBC ghost membrane, however, was not correlated with age, age of onset, daily haloperidol dose, plasma haloperidol levels, plasma cholesterol concentrations, or the duration of illness, haloperidol treatment or drug-free period. Thus, the present data demonstrate that RBC membrane fluidity is not affected by haloperidol treatment. Following haloperidol withdrawal, however, those patients with decreased RBC membrane fluidity, which correlated with increased psychosis, may be prone to relapse within 6 weeks.