Case report:: A typical Toxoplasma gondii strain from a free-living jaguar (Panthera onca) in French Guiana
Case report:: A typical Toxoplasma gondii strain from a free-living jaguar (Panthera onca) in French Guiana
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DOI：
10.4269/ajtmh.2008.78.195
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Carme, B.
中科院分区：
文献类型：
--
作者：
Demar, M.;Ajzenberg, D.;Carme, B.
与家猫一样，野生猫科动物也参与了弓形虫的整个感染周期，因为它们可以在胃肠道中寄生性成熟的寄生虫，并在粪便中排出感染性卵囊。我们报告，据我们所知，第一个分离和分子特征的T。从法属圭亚那的一只自由生活的美洲虎（Panthera onca）的心脏组织中提取的弓形虫菌株。在6个多态性标记的测序表明，美洲虎分离株有一个非典型的基因型，包括TgM-A等位基因以前只发现在分离株来自南美洲，和一个等位基因在GRA 6，这是以前只在加州海獭分离株报道。这些发现与最近描述的非典型弓形虫株参与严重的弓形虫病免疫功能正常的患者在法属圭亚那，似乎与一个新热带森林为基础的周期，涉及野猫和他们的猎物。
Like domestic cats, wild felids are involved in the complete infective cycle of Toxoplasma gondii because they can host in their gastrointestinal tract sexually mature parasites and shed infective oocysts in their feces. We report, to our knowledge, the first isolation and molecular characterization of a T. gondii strain from the heart tissue of a free-living jaguar (Panthera onca) in French Guiana. Sequencing at six polymorphic markers indicated that the jaguar isolate had an atypical genotype, including an allele at TgM-A previously found only in isolates from South America, and an allele at GRA6, which was previously reported only in Californian sea otter isolates. These findings are consistent with the recent description of atypical T gondii strains involved in severe toxoplasmoses in immunocompetent patients in French Guiana that seemed to be linked to a neotropical forest-based cycle involving wild cats and their prey.