The Internet-Based MGS2 Control Sample: Self Report of Mental Illness
The Internet-Based MGS2 Control Sample: Self Report of Mental Illness
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DOI：
10.1176/appi.ajp.2010.09071050
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发表时间：
2010-07-01
影响因子：
17.7
通讯作者：
Gejman, Pablo V.
中科院分区：
文献类型：
--
作者：
Sanders, Alan R.;Levinson, Douglas F.;Gejman, Pablo V.
目的：精神分裂症分子遗传学 (MGS2) 项目招募了非西班牙裔欧洲血统 (N = 3,364) 和非裔美国人 (N = 1,301) 受试者的成人对照样本。方法：受试者同意将表型数据和血液样本存入存储库供一般研究使用，并且样本完全匿名。作者将对照样本与人口普查数据进行了人口统计数据比较，并与之前的人口调查进行了人体测量学和通过互联网管理的问卷估计的精神疾病患病率的人口调查。结果：完整的 MGS2 对照样本包括 4,665 名受试者（欧洲血统：N = 3,364；非洲裔美国人：N = 1,301），其中 3,626 名受试者包含在 MGS2 全基因组范围内关联研究（GWAS）。尽管所有阶层都有代表性，但样本在人口统计学上总体上代表了美国人口，但年龄较大、女性较多、受过教育且富裕的人除外。自我报告的血统与基因型和人口普查数据一致。抑郁、焦虑和药物滥用诊断的终生患病率高于之前基于人群的调查，这可能是由于使用了简短的自我报告工具。然而，性别比例、合并症和人口关联等模式与之前的报告一致。互联网收集/评估的对照样本的 DNA 质量与面对面病例样本的 DNA 质量相当。结论：基于互联网的方法促进了快速收集大量匿名非西班牙裔欧洲血统和非裔美国人对照样本，这些样本已被验证为普遍代表人口学、血统和发病率的许多方面。利用与科学界共享的临床筛查数据可能允许研究人员为某些研究选择适当的对照。 （《美国精神病学杂志》2010 年；167：854-865）
Objective: The Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N = 3,364) and African American (N = 1,301) subjects.Method: Subjects gave consent to deposit phenotypic data and blood samples into a repository for general research use, with full anonymization of the sample. The authors compared the control sample with population census data for demographic data and with previous population surveys for anthropometrics and prevalences of psychiatric disorders as estimated by an Internet-administered questionnaire.Results: The full MGS2 control sample includes 4,665 subjects (European-ancestry: N = 3,364; African American: N = 1,301), of whom 3,626 were included in the MGS2 genome-wide association study (GWAS). The sample is generally demographically representative of the U.S. population, except for being older and more female, educated, and affluent, although all strata are represented. Self-reported ancestry was consistent with genotypic and census data. Lifetime prevalences for depressive, anxiety, and substance use diagnoses were higher than in previous population-based surveys, probably due to use of an abbreviated self-report instrument. However, patterns such as sex ratios, comorbidity, and demographic associations were consistent with previous reports. DNA quality for the Internet collected/evaluated control sample was comparable to that of the face-to-face case sample.Conclusions: The Internet-based methods facilitated the rapid collection of large and anonymized non-Hispanic European-ancestry and African American control samples that have been validated as being generally representative for many aspects of demography, ancestry, and morbidity. Utilization of clinical screening data shared with the scientific community may permit investigators to select appropriate controls for some studies. (Am J Psychiatry 2010; 167:854-865)