Working with memory: evidence for a role for the medial prefrontal cortex in performance monitoring during spatial delayed alternation
Working with memory: evidence for a role for the medial prefrontal cortex in performance monitoring during spatial delayed alternation
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DOI：
10.1152/jn.01192.2011
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发表时间：
2012-12-01
影响因子：
2.5
通讯作者：
Laubach, Mark
中科院分区：
文献类型：
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作者：
Horst, Nicole K.;Laubach, Mark
作者声明：John M.记忆工作：内侧前额叶皮层在空间延迟交替期间性能监控中作用的证据。J Neurophysiol 108：3276-3288，2012.首次发表于2012年9月26日; doi：10.1152/jn.01192.2011.-在大鼠执行操作性空间延迟交替任务时，记录内侧前额叶皮层（mPFC）神经元锋电位活动。神经元的敏感性，选择，结果和时间信息相关方面的任务进行了检查。大约三分之一的神经元对延迟反应的位置敏感，而动物在两个空间上不同的反应端口之一。然而，更少的神经元（< 10%）在延迟期间保持选择信息，每个神经元仅在延迟的一部分中表现出持续的放电率差异。另外三分之一的细胞编码有关行为结果的信息，其中一些神经元（占所有细胞的20%）在正确和不正确的反应之前以不同的速率发射（即，结果的预期编码）。其他细胞对奖励相关的反馈刺激（> 20%），前一次试验的结果（回顾性编码，5-10%）和/或自上次试验以来的时间（10-20%）敏感。对记录部位的解剖学分析发现，对选择、时间和结果信息敏感的细胞混合在mPFC的中间层内。总之，我们的研究结果表明，空间处理只是驱动mPFC神经元在空间工作记忆任务中变得活跃的一部分。我们建议，mPFC在这些任务中的主要作用是通过编码有关最近试验结果的信息来监测行为表现，以指导对当前试验的期望和反应。通过对这些变量进行编码，mPFC能够对行动进行控制，并确保有效和高效地执行任务。
Horst NK, Laubach M. Working with memory: evidence for a role for the medial prefrontal cortex in performance monitoring during spatial delayed alternation. J Neurophysiol 108: 3276-3288, 2012. First published September 26, 2012; doi:10.1152/jn.01192.2011.-Neuronal spike activity was recorded in the medial prefrontal cortex (mPFC) as rats performed an operant spatial delayed alternation task. The sensitivities of neurons to choice, outcome, and temporal information-related aspects of the task were examined. About one-third of neurons were sensitive to the location of delayed responding while animals were at one of two spatially distinct response ports. However, many fewer neurons (< 10%) maintained choice information over the delay, each exhibiting persistent differences in firing rates for only a portion of the delay. Another third of cells encoded information about behavioral outcomes, and some of these neurons (> 20% of all cells) fired at distinct rates in advance of correct and incorrect responses (i.e., prospective encoding of outcome). Other cells were sensitive to reward-related feedback stimuli (> 20%), the outcome of the preceding trial (retrospective encoding, 5-10%), and/or the time since a trial was last performed (10-20%). An anatomical analysis of the recording sites found that cells that were sensitive to choice, temporal, and outcome information were commingled within the middle layers of the mPFC. Together, our results suggest that spatial processing is only part of what drives mPFC neurons to become active during spatial working memory tasks. We propose that the primary role of mPFC in these tasks is to monitor behavioral performance by encoding information about recent trial outcomes to guide expectations and responses on the current trial. By encoding these variables, the mPFC is able to exert control over action and ensure that tasks are performed effectively and efficiently.