Norselic Acids A-E, Highly Oxidized Anti-infective Steroids that Deter Mesograzer Predation, from the Antarctic Sponge Crella sp.
Norselic Acids A-E, Highly Oxidized Anti-infective Steroids that Deter Mesograzer Predation, from the Antarctic Sponge Crella sp.
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DOI：
10.1021/np900382x
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发表时间：
2009-10-01
影响因子：
5.1
通讯作者：
Baker, Bill J.
中科院分区：
文献类型：
--
作者：
Ma, Wai S.;Mutka, Tina;Baker, Bill J.
从南极海绵Crella sp.中分离得到5个新甾体化合物，命名为去甲硒酸A-E（1-5）。通过广泛的NMR光谱和质谱研究建立了去甲硒酸的平面结构，并通过X射线晶体学阐明了去甲硒酸A（1）的构型。去甲硒酸A对甲氧西林耐药金黄色葡萄球菌（MRSA）、甲氧西林敏感的S。金黄色葡萄球菌（MSSA）、耐万古霉素屎肠球菌（VRE）和白色念珠菌，并减少同域中食动物的食物颗粒消耗。化合物1-5在低微摩尔水平下也具有抗利什曼原虫的活性。
Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp. collected in Antarctica. The planar structures of the norselic acids were established by extensive NMR spectroscopy and mass spectrometry studies, and the configuration of norselic acid A (1) was elucidated by X-ray crystallography. Norselic acid A displays antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive S. aureus (MSSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans and reduces consumption of food pellets by sympatric mesograzers. Compounds 1-5 are also active against the Leishmania parasite at low micromolar levels.