HIGH-INCIDENCE OF EGF RECEPTOR HYPERPRODUCTION IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMAS
HIGH-INCIDENCE OF EGF RECEPTOR HYPERPRODUCTION IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMAS
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DOI：
10.1002/ijc.2910390311
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发表时间：
1987-03-15
影响因子：
6.4
通讯作者：
SHIMIZU, N
中科院分区：
文献类型：
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作者：
OZAWA, S;UEDA, M;SHIMIZU, N
研究了31例食管鳞状细胞癌组织中EGF受体水平。其中22例（71%）癌组织的125I-EGF结合活性明显高于邻近非癌组织的正常黏膜。然后根据病理结果，包括淋巴结转移、浸润深度、分化类型、血管浸润、浸润和病变位置，比较这些EGF受体水平。与以往关于乳腺癌和膀胱癌的报道不同，我们的研究显示食管癌的这些病理特征与EGF受体水平之间没有明显的相关性。抗EGF受体单克隆抗体免疫组化染色检测癌组织鳞状细胞及附近正常上皮基底细胞中EGF受体。由于基底细胞在食管中具有增殖潜能，因此这些细胞中EGF受体水平的升高可能与人食管鳞状细胞癌的发生有关。
EGF receptor levels were investigated in esophageal squamous-cell carcinoma tissues from 31 patients. Twenty-two (71%) of these cancer tissues exhibited significantly higher 125I-EGF binding activity than normal mucosa in the adjacent noncancerous tissues. These EGF receptor levels were then compared on the basis of pathological findings including lymphnode metastasis, depth of invasion, differentiation type, vascular invasion, infiltration and location of the lesion. Unlike previous reports on breast and bladder cancers, our study showed no obvious correlation between these pathological characteristics and the EGF receptor levels in esophageal carcinomas. Immunohistochemical staining with the anti-EGF receptor monoclonal antibody detected EGF receptors in squamous cells of the cancer tissues as well as in the basal cells of nearby normal epithelium. Since the basal cells have proliferative potential in the esophagus, the increase in EGF receptor levels in these cells may possibly be associated with the development of human esophageal squamous-cell cancer.