A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
复制标题
DOI：
10.1016/s0092-8674(00)80536-x
复制
发表时间：
1997-08-22
期刊：
影响因子：
64.5
通讯作者：
Dulac, C
中科院分区：
文献类型：
--
作者：
Herrada, G;Dulac, C
哺乳动物保留了两个功能和解剖学上独立的嗅觉神经元集合，位于主嗅上皮和犁鼻器（VNO）。信息素激活VNO以引起与动物繁殖和攻击有关的固定动作行为和神经内分泌变化。差异筛选的cDNA文库构建从个别大鼠VNO神经元的分离，导致一个新的家庭的类似的100个基因编码的7个跨膜受体与Ca2+敏感和代谢型谷氨酸受体的序列相似性。这些基因可能编码一个新的信息素受体家族。受体基因表达的模式表明，VNO被组织成离散的和性二态的功能单位，可能允许分离的信息素信号导致特定阵列的行为和神经内分泌反应。
Mammals have retained two functionally and anatomically independent collections of olfactory neurons located in the main olfactory epithelium and in the vomeronasal organ (VNO). Pheromones activate the VNO in order to elicit fixed action behaviors and neuroendocrine changes involved in animal reproduction and aggression. Differential screening of cDNA libraries constructed from individual rat VNO neurons has led to the isolation of a novel family of similar to 100 genes encoding seven transmembrane receptors with sequence similarity with Ca2+-sensing and metabotropic glutamate receptors. These genes are likely to encode a novel family of pheromone receptors. Patterns of receptor gene expression suggest that the VNO is organized into discrete and sexually dimorphic functional units that may permit segregation of pheromone signals leading to specific arrays of behaviors and neuroendocrine responses.