Late-life anemia is associated with increased risk of recurrent falls
Late-life anemia is associated with increased risk of recurrent falls
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DOI：
10.1111/j.1532-5415.2005.00491.x
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发表时间：
2005-12-01
影响因子：
6.3
通讯作者：
Deeg, DJH
中科院分区：
文献类型：
--
作者：
Penninx, BWJH;Pluijm, SMF;Deeg, DJH
目的：检查贫血是否与反复跌倒的较高发生率相关。设计：前瞻性队列研究。地点：荷兰社区居住样本。参与者：阿姆斯特丹纵向衰老研究的 394 名 65 至 88 岁参与者。测量：根据世界卫生组织的标准，贫血的定义为女性血红蛋白浓度低于 12 g/dL，女性血红蛋白浓度低于 13 g/dL。男性的克/分升。使用参与者每周填写的秋季日历前瞻性地确定跌倒情况，持续三年。反复跌倒者被确定为在 3 年随访期间 6 个月内至少跌倒两次的人。 结果：在 394 人中，11.9%（18 名女性和 29 名男性）患有贫血。贫血者反复跌倒的发生率为 38.3%，而非贫血者为 19.6% (P = .004)。调整性别、年龄、体重指数和疾病后，贫血与反复跌倒风险增加 1.91 倍显着相关（95% 置信区间 = 1.09-3.36）。身体机能差（以肌肉力量、身体机能和限制为代表）在一定程度上介导了贫血与反复跌倒发生率之间的关联。结论：晚年贫血很常见，并且与反复跌倒风险增加一倍相关。肌肉无力和身体表现不佳似乎在一定程度上介导了这种关联。
OBJECTIVES: To examine whether anemia is associated with a higher incidence of recurrent falls.DESIGN: Prospective cohort study.SETTING: Community-dwelling sample in the Netherlands.PARTICIPANTS: Three hundred ninety-four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam.MEASUREMENTS: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration less than 12 g/dL in women and less than 13 g/dL in men. Falls were prospectively determined using fall calendars that participants filled out weekly for 3 years. Recurrent fallers were identified as those who fell at least two times within 6 months during the 3-year follow-up.RESULTS: Of the 394 persons, 11.9% (18 women and 29 men) had anemia. The incidence of recurrent falls was 38.3% of anemic persons versus 19.6% of nonanemic persons (P = .004). After adjustment for sex, age, body mass index, and diseases, anemia was significantly associated with a 1.91 times greater risk for recurrent falls (95% confidence interval = 1.09-3.36). Poor physical function (indicated by muscle strength, physical performance, and limitations) partly mediated the association between anemia and incidence of recurrent falls.CONCLUSION: Late-life anemia is common and associated with twice the risk of recurrent falls. Muscle weakness and poor physical performance appear to partly mediate this association.