Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy.
Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy.
复制标题
滑液分析可检测和区分犬骨关节炎和废用性萎缩实验模型中的蛋白多糖代谢。
DOI：
10.1007/978-3-0348-7442-7_5
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Caterson,B
中科院分区：
文献类型：
--
作者：
Ratcliffe,A;Beauvais,PJ;Saed-Nejad,F;Shurety,W;Caterson,B
采用犬实验性骨关节炎（OA）和废用性萎缩模型研究软骨代谢。来自OA关节的滑液显示硫酸角质素（KS）表位和连接蛋白水平升高，表明软骨素增加。对废用性萎缩关节液的分析显示KS表位水平较高，但连接蛋白没有增加。一种新的硫酸软骨素（3B3）表位的定量显示，它只存在于关节滑液和关节软骨的OA关节。结果表明，这些可能是退行性关节疾病的重要指标或标志物。
Canine experimental models of osteoarthritis (OA) and disuse atrophy were used to study cartilage metabolism. The synovial fluids from the OA joints showed elevated levels of keratan sulfate (KS) epitope and link protein, indicating increased catabolism. Analysis of fluids from joints with disuse atrophy showed high levels of KS epitope, but no increase in link protein. Quantitation of a novel chondroitin sulfate (3B3) epitope showed it to be present only in the synovial fluids and articular cartilage of the OA joints. The results indicate that these may be important indicators, or markers, of degenerative joint disease.