TUMOR-INITIATING ACTIVITY OF QUINOLINE AND METHYLATED QUINOLINES ON THE SKIN OF SENCAR MICE
TUMOR-INITIATING ACTIVITY OF QUINOLINE AND METHYLATED QUINOLINES ON THE SKIN OF SENCAR MICE
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DOI：
10.1016/0304-3835(84)90162-9
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发表时间：
1984-01-01
期刊：
影响因子：
9.7
通讯作者：
HOFFMANN, D
中科院分区：
文献类型：
--
作者：
LAVOIE, EJ;SHIGEMATSU, A;HOFFMANN, D
在十四烷酰佛波醇乙酸酯的促进下，测定了喹啉和甲基喹啉的所有 7 个位置异构体对 SENCAR 雌性小鼠皮肤的肿瘤引发活性。喹啉或异构甲基喹啉的总起始剂量为每只小鼠 7.5 mg。喹啉在 53% 的小鼠中诱发肿瘤（每只动物 0.73 个肿瘤）。虽然2-、3-、5-和7-甲基喹啉在该测定中没有表现出显着的致瘤活性，但4-甲基喹啉在45%的小鼠中诱导肿瘤（每只动物0.90个肿瘤）。 8-甲基喹啉在 45% 的小鼠中诱发肿瘤（每只动物 0.66 个肿瘤）。
Quinoline and all 7 positional isomers of methylquinoline were assayed for tumor-initiating activity on the skin of SENCAR female mice with promotion by tetradecanoyl phorbol acetate. The total initiation dose of quinoline or the isomeric methylquinolines was 7.5 mg per mouse. Quinoline induced tumors in 53% of the mice (0.73 tumors per animal). While 2-, 3-, 5- and 7-methylquinoline did not exhibit significant tumorigenic activity in this assay, 4-methylquinoline induced tumors in 45% of the mice (0.90 tumors per animal). 8-Methylquinoline induced tumors in 45% of the mice (0.66 tumors per animal).