Alcohol decreases insulin sensitivity in healthy subjects.
Alcohol decreases insulin sensitivity in healthy subjects.
复制标题
酒精会降低健康受试者的胰岛素敏感性。
DOI：
10.1093/oxfordjournals.alcalc.a044770
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发表时间：
1988
影响因子：
2.8
通讯作者：
J. H. Shah
中科院分区：
文献类型：
--
作者：
J. H. Shah
为了研究酒精对葡萄糖和胰岛素代谢的影响，健康志愿者同时输注葡萄糖和胰岛素 150 分钟，一次是在饮酒期间，一次是在摄入无热量姜汁（对照）期间。饮酒期间，平均稳态（100 至 150 分钟）血糖为 5.44 +/- 0.39 mmol/l。平均稳态胰岛素水平为 6.3 +/- 1.1 ng/ml，显着高于对照状态期间观察到的水平（4.0 +/- 0.39 mmol/l 葡萄糖和 4.4 +/- 0.6 ng/ml 胰岛素）。尽管稳态胰岛素浓度较高，但饮酒期间葡萄糖代谢显着降低。这些发现表明酒精引起的葡萄糖代谢受损是由于组织对胰岛素的敏感性降低引起的。
To study the effect of alcohol on glucose and insulin metabolism, a simultaneous infusion of glucose and insulin was given for 150 min to healthy volunteers, once during alcohol and once during calorie-free gingerale (control) ingestion. During alcohol intake, the average steady-state (between 100 and 150 min) glucose of 5.44 +/- 0.39 mmol/l. and the average steady-state insulin of 6.3 +/- 1.1 ng/ml were significantly higher than those (4.0 +/- 0.39 mmol/l. of glucose and 4.4 +/- 0.6 ng/ml of insulin) observed during the control state. Despite the higher steady-state insulin concentrations, the glucose metabolism was significantly less during alcohol ingestion. These findings suggest alcohol-induced impairment in glucose metabolism is caused by a decreased tissue sensitivity to insulin.