Molecular mechanism of the photoperiodic response of gonads in birds and mammals
Molecular mechanism of the photoperiodic response of gonads in birds and mammals
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DOI：
10.1016/j.cbpa.2005.09.009
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发表时间：
2006-07-01
影响因子：
2.3
通讯作者：
Yoshimura, Takashi
中科院分区：
文献类型：
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作者：
Yoshimura, Takashi
各种季节过程的适当时机对于生活在温带地区的动物的生存和繁殖成功至关重要。当季节性繁殖的动物每年的日长发生变化时，神经内分泌性腺活动就会发生巨大的变化。然而，所有生物体性腺光周期反应的分子机制仍然未知。众所周知，生物钟在某种程度上参与了光周期的调节。最近，在日本鹌鹑的下丘脑内侧基底层（MBH）中观察到生物钟基因的节律表达。 MBH被认为是光周期论的中心。此外，MBH 中的脱碘酶长日照诱导的激素原甲状腺素 (T-4) 向生物活性三碘甲状腺原氨酸 (T-3) 的转化已被证明对性腺的光周期反应很重要。尽管长期以来人们认为鸟类和哺乳动物性腺光周期反应的调节机制有很大不同，但仓鼠下丘脑中长日照诱导的脱碘酶基因表达表明鸟类和哺乳动物光周期存在保守的调节机制。 (c) 2005 Elsevier Inc. 保留所有权利。
Appropriate timing of various seasonal processes is crucial to the survival and reproductive success of animals living in temperate regions. When seasonally breeding animals are subjected to annual changes in day length, dramatic changes in neuroendocrine-gonadal activity take place. However, the molecular mechanism underlying the photoperiodic response of gonads remains unknown for all living organisms. It is well known that a circadian clock is somehow involved in the regulation of photoperiodism. Recently, rhythmic expression of circadian clock genes was observed in the mediobasal hypothalamus (MBH) of Japanese quail. The MBH is believed to be the center for photoperiodism. In addition, long-day-induced hormone conversion of the prohormone thyroxine (T-4) to the bioactive triiodothyronine (T-3) by deiodinase in the MBH has been proven to be important to the photoperiodic response of the gonads. Although the regulating mechanism for the photoperiodic response of gonads in birds and mammals has long been considered to be quite different, the long-day-induced expression of the deiodinase gene in the hamster hypothalamus suggests the existence of a conserved regulatory mechanism in avian and mammalian photoperiodism. (c) 2005 Elsevier Inc. All rights reserved.