THE RELATION BETWEEN SURVIVAL AND AGE AT DIAGNOSIS IN BREAST-CANCER
THE RELATION BETWEEN SURVIVAL AND AGE AT DIAGNOSIS IN BREAST-CANCER
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DOI：
10.1056/nejm198608283150906
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发表时间：
1986-08-28
影响因子：
158.5
通讯作者：
STONE, B
中科院分区：
文献类型：
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作者：
ADAMI, HO;MALKER, B;STONE, B
我们分析了1960年至1978年诊断为乳腺癌的57,068名瑞典妇女（约占所有病例的98%）的诊断年龄与相对生存率（观察生存率与预期生存率的比值）之间的关系。45至49岁的女性预后最好，在不同的观察时期，相对生存率超过最年轻患者（<30岁）7.6%至12.9%。49岁以后的相对存活率明显下降，特别是在50至59岁的妇女中，年龄最大的妇女（>75岁）的存活率最低。75岁以上患者与45岁至49岁患者之间的相对生存率差异从2年时的8.6%增加到5年、10年和15年随访后的12.2%、20.3%和27.5%。在绝经前年龄段，乳腺癌的长期年死亡率接近1%至2%，但在整个观察期间，最大年龄组的死亡率超过5%。了解年龄和预后之间复杂关系的生物学基础可能会更好地了解女性乳腺癌的自然史。（N Engl J Med 1986;315：559-63.）
We analyzed the relation between age at diagnosis and relative survival (ratio of observed to expected survival) in 57,068 women in Sweden in whom breast cancer was diagnosed in 1960 to 1978 (about 98 percent of all cases). Women who were 45 to 49 years old had the best prognosis, with a relative survival exceeding that of the youngest patients (<30 years) by 7.6 to 12.9 percent at different periods of observation. Relative survival declined markedly after the age of 49 — particularly in women aged 50 to 59 — and the oldest women (>75) had the worst rate. The difference in relative survival between those older than 75 and those 45 to 49 increased from 8.6 percent at 2 years to 12.2, 20.3, and 27.5 percent after 5, 10, and 15 years of follow-up, respectively. The long-term annual mortality rate due to breast cancer approached 1 to 2 percent at the premenopausal ages but exceeded 5 percent throughout the period of observation in the oldest age group. An understanding of the biologic basis for the complex relation between age and prognosis might provide a better understanding of the natural history of breast cancer in women. (N Engl J Med 1986;315:559–63.)