Importance of substrate competition in the mechanism of insulin resistance in man.
Importance of substrate competition in the mechanism of insulin resistance in man.
复制标题
底物竞争在人类胰岛素抵抗机制中的重要性。
DOI：
10.1016/0026-0495(87)90105-3
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Felber
中科院分区：
文献类型：
--
作者：
D. Vouillamoz;E. Temler;E. Jéquier;J. Felber
在7名正常受试者中，通过连续间接量热法比较了葡萄糖或果糖（0.5 g/kg × h）在2小时内输注诱导的碳水化合物（CHO）氧化，持续160分钟，无或伴随输注Intralidid（一种中性脂肪乳剂）。葡萄糖输注伴随着血糖（99 ± 10 mg/dL）和胰岛素（36 ± 7 μU/mL）血浆水平高于基础值，胰岛素输注期间两条曲线进一步升高（140 ± 7 mg/dL和53 ± 12 μU/mL）。相比之下，果糖输注期间血糖和胰岛素仅极轻微升高（未输注Intralidid时分别为3.5 ± 2.9 mg/dL和5.3 ± 1.4 μU/mL，输注Intralidid时分别为10.6 ± 2.1 mg/dL和9.6 ± 2.0 μU/mL）。在两小时的糖输注过程中，输注了平均68.7 g葡萄糖或果糖。在160分钟的试验中，葡萄糖输注的总CHO氧化为15.6 ± 1.2 g，果糖输注的总CHO氧化为21.6 ± 2.6 g。在Intraperoid输注期间，CHO氧化受到抑制，葡萄糖输注的值为5.9 ± 1.3 g（P< .005），果糖输注的值为13.8 ± 1.8 g（P< .05）。在Intraperoid输注期间，两种情况下的脂质氧化均增加。这些结果表明，在葡萄糖输注中观察到的脂质诱导的CHO氧化抑制在一定程度上也发生在果糖中，表明胰岛素可能不主要参与。他们提出了在脂肪代谢升高期间胰岛素抵抗的代谢起源。
Carbohydrate (CHO) oxidation induced by a glucose or fructose (0.5 g/kg × h) infusion over two hours was compared for 160 minutes by means of continuous indirect calorimetry in seven normal subjects without or with a concomitant infusion of Intralipid, a neutral fat emulsion. The glucose infusion was accompanied by a rise over basal values in both glucose (99 ± 10 mg/dL) and insulin (36 ± 7 μU/mL) plasma levels, with a further rise of both curves during the Intralipid infusion (140 ± 7 mg/dL and 53 ± 12 μU/mL). By contrast, plasma glucose and insulin rose only minimally during the fructose infusion (3.5 ± 2.9 mg/dL and 5.3 ± 1.4 μU/mL, respectively, without Intralipid, and 10.6 ± 2.1 mg/dL and 9.6 ± 2.0 μU/mL with Intralipid). During the two-hour sugar infusion, a mean quantity of 68.7 g glucose or fructose was infused. The total CHO oxidation was 15.6 ± 1.2 g for glucose and 21.6 ± 2.6 for fructose infusion for the 160 minutes of the test. During the Intralipid infusion, CHO oxidation was inhibited with values of 5.9 ± 1.3 g for glucose (P< .005) and 13.8 ± 1.8 g (P< .05) for fructose infusion. Lipid oxidation was increased in both cases during the Intralipid infusion. These results show that the lipid-induced inhibition of CHO oxidation observed with glucose infusion also occurs to some extent with fructose, suggesting that insulin might not be primarily involved. They suggest a metabolic origin for insulin resistance during elevated fat metabolism.
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA