Isolation and biological evaluation of filiformin, plakortide F, and plakortone G from the Caribbean sponge Plakortis sp.
Isolation and biological evaluation of filiformin, plakortide F, and plakortone G from the Caribbean sponge Plakortis sp.
复制标题
DOI：
10.1021/np010216u
复制
发表时间：
2001-11-01
影响因子：
5.1
通讯作者：
Hamann, MT
中科院分区：
文献类型：
--
作者：
Gochfeld, DJ;Hamann, MT
对牙买加海绵Plakortis sp.的抗疟提取物进行生物测定和光谱引导分离，分离出三种代谢物。先前报道的溴芳丝状双胍(1)是从我们的Plakortis sp.样品中获得的，并讨论了该化合物的潜在来源。含过氧化物的代谢物plakortide F(2)是一种更典型的Plakortis代谢物，并在体外显示出对恶性疟原虫的显著活性。本文还报道了一种新的内酯plakortone G(3)的分离、结构和生物活性。
The bioassay- and spectroscopic-guided fractionation of the antimalarial extract from a Jamaican sponge, Plakortis sp., resulted in the isolation of three metabolites. The previously reported bromoaromatic filiformin (1) was obtained from our sample of Plakortis sp., and the potential origins of this compound are discussed, The peroxide-containing metabolite, plakortide F (2), is a more typical Plakortis metabolite and was shown to exhibit significant activity against Plasmodium falciparum in vitro. The isolation, structure, and bioactivity of a new lactone, plakortone G (3), are also reported.