An Elevated Body Mass Index Increases Lung Volume but Reduces Airflow in Italian Schoolchildren
An Elevated Body Mass Index Increases Lung Volume but Reduces Airflow in Italian Schoolchildren
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DOI：
10.1371/journal.pone.0127154
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发表时间：
2015-05-13
期刊：
影响因子：
3.7
通讯作者：
Viegi, Giovanni
中科院分区：
文献类型：
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作者：
Cibella, Fabio;Bruno, Andreina;Viegi, Giovanni
哮喘和肥胖是世界范围内日益严重的重要健康问题。肥胖被认为是哮喘的一个危险因素，因为它会引起气道力学的改变和气道炎症的改变。方法我们横断面调查了生活在意大利巴勒莫的10-17岁健康儿童的大量人群样本中体重增加对肺功能的影响。体重对肺功能变量的解释作用采用多元线性回归模型，考虑身高、性别和年龄等级。结果2393名受试者FVC、FEV1与体重呈正相关。多元回归模型显示，FEV1的权重β系数显著低于FVC（分别为0.005和0.009 l/kg），说明体重对FVC和FEV1的解释作用程度不同。FEV1/FVC和FEF25-75%/FVC与体重呈显著负相关，FEF25-75%与体重无显著相关。通过敏感性分析，将807名有症状的受试者引入模型，也得到了类似的结果。结论健康儿童的FEV1和FVC随体重不成比例地增加，导致气流减少，导致肺功能明显变差，与呼吸系统疾病无关。
BackgroundAsthma and obesity are important and growing health issues worldwide. Obesity is considered a risk factor for asthma, due to the induction of changes in airway mechanics and altered airway inflammation.MethodsWe cross-sectionally investigated the effect of increased weight on pulmonary function in a large population sample of healthy children, aged 10-17 yrs living in Palermo, Italy. Explanatory effect of weight on lung function variables were evaluated by multiple linear regression models, taking into account height, gender, and age-class.ResultsAmong the 2,393 subjects, FVC and FEV1 were positively correlated to weight. Multiple regression models showed that the weight beta coefficient for FEV1 was significantly lower with respect to that for FVC (0.005 and 0.009 l/kg, respectively), indicating a different magnitude in explanatory effect of weight on FVC and FEV1. Both FEV1/FVC and FEF25-75%/FVC ratios were negatively correlated to weight, while FEF25-75% was not significantly correlated. Similar results were obtained also when 807 symptomatic subjects were introduced in the model through a sensitivity analysis.ConclusionIn healthy children, the disproportionate increase of FEV1 and FVC with weight produces airflow decrease and consequently apparent poorer lung function independently from respiratory disease status.