Chronic leukemia with a hybrid surface phenotype (T lymphocytic/myelomonocytic): leukemic cells displaying natural killer activity and antibody-dependent cellular cytotoxicity.
Chronic leukemia with a hybrid surface phenotype (T lymphocytic/myelomonocytic): leukemic cells displaying natural killer activity and antibody-dependent cellular cytotoxicity.
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具有混合表面表型的慢性白血病（T淋巴细胞/骨髓单核细胞）：白血病细胞表现出自然杀伤活性和抗体依赖性细胞毒性。
作者：
G. Schlimok;E. Thiel;E. Rieber;D. Huhn;H. Feucht;J. Lohmeyer;G. Riethmüller
慢性白血病患者表现出罕见的临床特征，如高丙种球蛋白血症和激活血管内凝血后，低剂量照射的脾脏肿大。光镜和电镜下，白血病细胞类似于大颗粒淋巴细胞。在其表面上同时表达以下标志物：绵羊红细胞受体和IgG的Fc部分;通过异源抗血清（HuTLA）和单克隆抗体（OKT 3，T411）显示的常见T细胞抗原;细胞毒性/抑制性T细胞（OKT 8，T811）共有的抗原以及OKM 1和M522单克隆抗体定义的骨髓单核细胞抗原。白血病细胞表现出自发性（NK）和抗体依赖性（ADCC）细胞毒性，但它们在体外不抑制B细胞分化。
A patient with chronic leukemia exhibited uncommon clinical features, such as hypergammaglobulinemia and activation of intravascular coagulation after low-dose irradiation of the enlarged spleen. By light and electron microscopy, the leukemic cells resembled large granular lymphocytes. The following markers were simultaneously expressed on their surface: receptors for sheep erythrocytes and the Fc part of IgG; common T-cell antigens as revealed by a heteroantiserum (HuTLA) and monoclonal antibodies (OKT3, T411); antigens shared by cytotoxic/suppressor T cells (OKT8, T811) as well as myelomonocytic antigens defined by the OKM1 and M522 monoclonal antibodies. The leukemic cells showed both spontaneous (NK) and antibody-dependent (ADCC) cytotoxicity, but they did not suppress B-cell differentiation in vitro.
描绘负责人体自然杀伤和抗体依赖性细胞毒性的效应器群体。
DOI：
10.1016/0090-1229(81)90018-0
发表时间：
1981
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Breard,J;Reinherz,EL;O'Brien,C;Schlossman,SF
通讯作者：
Schlossman,SF
自然杀伤 (NK) 和抗体依赖性细胞毒性 (ADCC) 效应器中 T 细胞性质和异质性的证据：与溶细胞 T 淋巴细胞 (CTL) 的比较。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fast,LD;Hansen,JA;Newman,W
通讯作者：
Newman,W