Symptomatic hypoglycemia:: An unusual side effect of oral purine analogues for treatment of ALL
Symptomatic hypoglycemia:: An unusual side effect of oral purine analogues for treatment of ALL
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DOI：
10.1002/pbc.20582
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发表时间：
2006-09-01
影响因子：
3.2
通讯作者：
Sanli, Fatih
中科院分区：
文献类型：
--
作者：
Bay, Ali;Oner, Ahmet Faik;Sanli, Fatih
在接受口服嘌呤类似物治疗儿童急性淋巴细胞白血病（ALL）的儿童中，症状性低血糖是一种罕见的并发症。抗代谢治疗降糖作用的确切机制尚不清楚。肝糖原储存减少或肝糖异生受损可能是低血糖的部分原因。为了防止低血糖，建议睡前吃含复合碳水化合物的食物。在6-巯基嘌呤（6-MP）引起的严重低血糖病例中，可以在早晨给药，如果失败，可以短时间停用6-MP。我们报告了一个3岁的儿童，他在接受非高风险ALL治疗后降低6-MP后出现严重的清晨低血糖发作。
Symptomatic hypoglycemia is an unusual complication in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia (ALL). The exact mechanism of the hypoglycemic effect of the antimetabolic therapy remains unclear. Reduced hepatic glycogen stores or impaired hepatic glyconeogenesis may partly explain the hypoglycemia. To prevent hypoglycemia, food containing complex carbohydrates is recommended before sleep. In severe cases of hypoglycemia due to 6-mercaptopurine (6-MP), the dose can be given in the morning and if this fails 6-MP can be discontinued for a short period of time. We report a 3-year-old child who developed severe early morning hypoglycemia episodes that resolved after decreasing 6-MP while receiving non-high risk ALL therapy.