Stress, depression, and coronary artery disease: Modeling comorbidity in female primates
Stress, depression, and coronary artery disease: Modeling comorbidity in female primates
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DOI：
10.1016/j.neubiorev.2008.06.006
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发表时间：
2009-02-01
影响因子：
8.2
通讯作者：
Willard, Stephanie L.
中科院分区：
文献类型：
--
作者：
Shively, Carol A.;Musselman, Dominique L.;Willard, Stephanie L.
抑郁症和冠心病是造成妇女疾病负担的主要原因。CND和抑郁症是合并症；他们是否有共同的病因或抑郁症导致冠心病尚不清楚。冠心病的潜在病理，冠状动脉粥样硬化（CAA），在冠心病发生几十年前就已经存在，而抑郁症与CAA之间的时间关系尚不清楚。本文综述了食蟹猴CAA与抑郁症的一种已建立的模型——早期CAA中抑郁症参与的证据。与人类一样，猴子在社会地位低下的压力下可能会表现出抑郁行为，并伴有下丘脑-垂体-肾上腺（HPA）、自主神经系统、脂质代谢、卵巢和神经5 -羟色胺能系统功能的紊乱，这些都与CAA的加剧有关。灵长类动物的数据与抑郁可能导致CAA的假设一致，也与CAA和抑郁症可能是社会压力的结果的假设一致。需要更多的研究来区分这两种可能性。灵长类动物的数据描绘了一幅令人信服的画面：抑郁症是一种全身疾病。(C) 2008 Elsevier Ltd版权所有。
Depression and coronary heart disease (CND) are leading contributors to disease burden in women. CND and depression are comorbid; whether they have common etiology or depression causes CHD is unclear. The underlying pathology of CHID, coronary artery atherosclerosis (CAA), is present decades before CHID, and the temporal relationship between depression and CAA is unclear. The evidence of involvement of depression in early CAA in cynomolgus monkeys, an established model of CAA and depression, is summarized. Like people, monkeys may respond to the stress of low social status with depressive behavior accompanied by perturbations in hypothalamic-pituitary-adrenal (HPA), autonomic nervous system, lipid metabolism, ovarian, and neural serotonergic system function, all of which are associated with exacerbated CAA. The primate data are consistent with the hypothesis that depression may cause CAA, and also with the hypothesis that CAA and depression may be the result of social stress. More study is needed to discriminate between these two possibilities. The primate data paint a compelling picture of depression as a whole-body disease. (C) 2008 Elsevier Ltd. All rights reserved.