Ubiquitination-mediated autophagy against invading bacteria
Ubiquitination-mediated autophagy against invading bacteria
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DOI：
10.1016/j.ceb.2011.03.003
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发表时间：
2011-08-01
影响因子：
7.5
通讯作者：
Yoshimori, Tamotsu
中科院分区：
文献类型：
--
作者：
Fujita, Naonobu;Yoshimori, Tamotsu
自噬主要是一种非选择性的细胞内整体降解过程。然而，最近的研究表明，泛素阳性底物，如蛋白质聚集体，线粒体，过氧化物酶体和入侵的细菌，通过自噬选择性地靶向溶酶体。因此，泛素化似乎是哺乳动物细胞中选择性自噬的一般标记。本文综述了自噬如何通过泛素化隔离入侵细菌的现有模型。
Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.