Some parameters of conditioned immunosuppression: species difference and CS-US delay.
Some parameters of conditioned immunosuppression: species difference and CS-US delay.
复制标题
条件性免疫抑制的一些参数：物种差异和 CS-US 延迟。
DOI：
10.1016/0031-9384(86)90361-6
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发表时间：
1986
影响因子：
2.9
通讯作者：
Titus,MJ
中科院分区：
文献类型：
--
作者：
McCoy,DF;Roszman,TL;Miller,JS;Kelly,KS;Titus,MJ
进行了三个实验，其中疾病诱导的免疫抑制剂，环磷酰胺（无条件刺激，美国）与先前提出的糖精溶液条件刺激（CS）。在每一个实验中，再次暴露于CS产生了实验组中的空斑形成细胞反应的条件性抑制。实验I用Fisher 344大鼠证明了这一结果。实验II用Balb/c小鼠复制了该效果。在实验III中，当小鼠接受CS-US延迟长达6小时时，证明了条件性免疫抑制。在行为学或免疫学数据中均不存在延迟梯度的证据。这些平行的发现并没有支持味觉厌恶和条件性免疫抑制过程之间分离的观点。
Three experiments were conducted in which an illness-inducing immunosuppressant, cyclophosphamide (an unconditioned stimulus, US) was associated with a previously presented saccharine solution conditioned stimulus (CS). In each experiment, reexposure to the CS produced a conditioned suppression of the plaque-forming-cell response in the experimental groups. Experiment I demonstrated this result with Fisher 344 rats. Experiment II replicated the effect with Balb/c mice. In Experiment III conditioned immunosuppression was demonstrated when mice received CS-US delays as long as 6 hours. No evidence of a delay gradient was present in either the behavioral or the immunologic data. These parallel findings offer no support for the idea of a dissociation between the taste aversion and conditioned immunosuppression processes.