Usage of veterinary therapeutic antimicrobials in Denmark, Norway and Sweden following termination of antimicrobial growth promoter use
Usage of veterinary therapeutic antimicrobials in Denmark, Norway and Sweden following termination of antimicrobial growth promoter use
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DOI：
10.1016/j.prevetmed.2006.02.003
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发表时间：
2006-07-17
影响因子：
2.6
通讯作者：
Bangen, M
中科院分区：
文献类型：
--
作者：
Grave, K;Jensen, VF;Bangen, M
丹麦、挪威和瑞典分别于1998-1999年、1995年和1986年淘汰了抗菌生长促进剂（AGPs）。丹麦动物治疗性抗菌剂的年使用量在AGP逐步淘汰期间（1988-1999年）和随后的2年中几乎翻了一番。增加主要是由于断奶仔猪中治疗性抗菌剂的消耗量增加。除1999年断奶猪停止使用AGP和次年外，治疗性抗菌剂使用量的年度增加与丹麦屠宰猪数量的年度增加相关性良好。在挪威，从1995年到2000年，动物治疗性抗菌剂的使用量下降了39%。2001-2003年期间，年度使用量保持在2000年的水平。在AGP停止后（从1995年到2003年），挪威每年生产的屠宰猪数量逐渐增加了10%。在瑞典，禁止AGP后的前2年（1986-1988年），动物中治疗性抗菌剂的使用量增加了21%，然后保持稳定，直到1994年;从1994年到2003年，这种使用量下降了47%。最初的增加是由于在肉鸡和断奶仔猪中使用量增加所致。2003年瑞典用于动物的剂量是1994年的一半。在研究期间，瑞典每年生产的屠宰猪数量逐渐下降了16%，尽管有所波动。在丹麦、挪威和瑞典，奶牛和肉牛的数量在各个研究期间仅略有下降，而肉鸡的产量显著增加，特别是在挪威和瑞典。在终止AGP后，丹麦动物中抗菌剂（AGP和治疗性抗菌剂）的总使用量下降了36%（从1996年至2003年）：在挪威，这一数字为45%（从1995年至2003年）。在瑞典，2003年动物抗菌剂的总使用量仅为1984年的三分之一（从51吨减少到16吨）。在瑞典和丹麦，终止AGP只是食用动物中治疗性抗菌剂使用增加的暂时风险因素;然而，丹麦断奶仔猪中的使用可能是例外。此外，停止使用AGP大大减少了丹麦、挪威和瑞典动物抗菌剂的总体年度使用量。(c)2006 Elsevier B. V.保留所有权利。
Antimicrobial growth promoters (AGPs) were phased out in Denmark, Norway and Sweden in 1998-1999, 1995 and 1986, respectively. The annual usage of therapeutic antimicrobials in animals in Denmark almost doubled during the period when AGPs were phased out (1988-1999) and in the subsequent 2 years. The increase was mainly due to an increased consumption of therapeutic antimicrobials in weaning pigs. The annual increase in usage of therapeutic antimicrobials and the annual increase in numbers of slaughter-swine produced in Denmark correlates well, except for 1999 when AGP use was discontinued in weaning pigs, and the following year. In Norway, the usage of therapeutic antimicrobials in animals decreased by 39% from 1995 to 2000. During 2001-2003 the annual usage remained at the 2000-level. The annual numbers of slaughter- swine produced in Norway increased gradually by 10% after the AGP discontinuation (from 1995 to 2003). In Sweden, the usage of therapeutic antimicrobials in animals increased by 21% the first 2 years subsequent to the AGP ban (1986-1988), remained then constant until 1994; from 1994 to 2003 this usage declined by 47%. The initial increase was caused by increased use in broilers and in weaning piglets. The amounts used in animals in Sweden in 2003 were half of the amounts used in 1994. The annual numbers of slaughter-swine produced in Sweden declined gradually by 16% in the study period, although fluctuating. In Denmark, Norway and Sweden the number of dairy cattle and beef cattle declined only slightly in the various study periods while numbers of broilers produced increased notably, especially in Norway and Sweden. Following the termination of AGPs the total usage of antimicrobials (AGPs and therapeutic antimicrobials) in animals in Denmark declined 36% (from 1996 to 2003): in Norway this figure was 45% (from 1995 to 2003). In Sweden, the total usage of antimicrobials in animals in 2003 amounted to only one third of the amounts used in 1984 (decreased from 51 to 16 tonnes). Termination of AGPs was only a temporary risk factor for increased usage of therapeutic antimicrobials in food-animals in Sweden and Denmark; however, an exception might be usage in weaning piglets in Denmark. Furthermore, the discontinuation of AGP use has decreased the overall annual usage of antimicrobials in animals in Denmark, Norway and Sweden considerably. (c) 2006 Elsevier B.V. All rights reserved.