Esculetin prevents liver damage induced by paracetamol and CCl4
Esculetin prevents liver damage induced by paracetamol and CCl4
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DOI：
10.1006/phrs.1997.0262
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发表时间：
1998-01-01
影响因子：
9.3
通讯作者：
Shah, BH
中科院分区：
文献类型：
--
作者：
Gilani, AH;Janbaz, KH;Shah, BH
研究了菊苣和九重葛中发现的酚类化合物-七叶壳对扑热息痛和四氯化碳诱导的肝损伤的可能保护作用。对乙酰氨基酚在IG kg（-1）剂量下对小鼠产生100%的死亡率，而用七叶酮（6 mg kg（-1））预处理动物将死亡率降低至40%。大鼠口服对乙酰氨基酚（640 mg kg（-1））可导致肝损伤，表现为血清碱性磷酸酶（ALP）和转氨酶（AST和ALT）水平升高。预先给大鼠服用七叶酮（6 mg kg（-1））可防止扑热息痛引起的血清酶升高。肝毒性剂量的CCl_4（1.5 ml/kg;口服）也可升高血清ALP、AST和ALT水平。相同剂量的七叶壳酮（6 mg kg（-1））能够阻止CCl 4诱导的血清酶升高。四叶草克还能防止CCl_4引起的戊巴比妥睡眠时间延长，具有保肝作用。这些结果表明，escuaoke具有抗肝毒性活性，并且这种化合物在菊苣和九重葛中的存在可以解释这些植物在肝损伤中的民间用途。(C)1998年意大利药理学会。
Esculetin, a phenolic compound found in Cichorium intybus and Bougainvllra spectabillis was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at the dose of Ig kg(-1) in mice while pre-treatment of animals with esculetin (6 mg kg(-1)) reduced the death rate to 40%. Oral administration of paracetamol (640 mg kg(-1)) produced liver damage in rats as manifested by the rise in serum enzyme levels of alkaline phosphatase (ALP) and aminotransferases (AST and ALT). Pre-treatment of rats with esculetin (6 mg kg(-1)) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 mi kg(-1); orally) also raised serum ALP, AST and ALT levels. The same dose of esculetin (6 mg kg(-1)) was able to prevent the CCl4-induced rise in serum enzymes. Esculetin also prevented CCl4-induced prolongation in pentobarbital sleeping time conforming hepatoprotectivity. These results indicate that esculetin possesses anti-hepatotoxic activity and the presence of this compound in Cichorium intybus and Bougainvllra spectabillis may explain the folkloric use of these plants in liver damage. (C) 1998 The Italian Pharmacological Society.