Short-lived mixed affective states in bipolar disorder.
Short-lived mixed affective states in bipolar disorder.
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双相情感障碍中短暂的混合情感状态。
DOI：
10.1016/j.psychres.2019.112496
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发表时间：
2020
影响因子：
11.3
通讯作者：
Eyler,LisaT
中科院分区：
文献类型：
--
作者：
Aftab,Awais;Depp,Colin;Daly,Rebecca;Huege,Steven;Sutherland,Ashley;Soontornniyomkij,Benchawanna;Eyler,LisaT
已知患有双相情感障碍的人具有情绪状态的快速变化，并且这些情绪变化可在数天和数周的过程内发生（Judd等人，2003年，2002年）。持续不到一天的情绪状态被假设存在，但研究和特征很少（Kramlinger和Post，1996; Tillman和Geller，2003）。对混合情绪的短暂状态的研究甚至更少（Swann等人，2013年）。文献中的这一空白对于填补混合症状与自杀倾向和情绪发作严重性的给定关联是重要的（Swann等人，我们使用了一项正在进行的纵向研究的基线数据，该研究检查了双相情感障碍患者的认知和炎症反应轨迹，以研究受试者主观报告的情绪状态的患病率，持续时间和关联，其中受试者将自己评为同时感到悲伤，快乐和精力充沛。我们的研究设计包括一天内最多3次自我报告的情感评级，这使我们能够以小时为单位探索情感状态的存在和持续时间。我们的样本包括50名I型和II型双相情感障碍（BD）参与者和91名健康对照参与者（HC）。双相情感障碍的诊断采用DSM-IV的结构化临床访谈进行确认。入选标准为诊断为双相I型或II型障碍，年龄≥ 25岁，目前为门诊患者，能够提供知情同意书。排除标准包括急性疾病或妊娠、近期疫苗接种、痴呆、癫痫发作、帕金森病、中风或头部创伤史、癌症治疗史、未控制的糖尿病/高血压等。
People with bipolar disorder are known to have rapid alterations in mood states, and these changes in mood may occur within the course of days and weeks (Judd et al., 2003, 2002). Mood states lasting less than a day are hypothesized to exist but have been poorly studied and characterized (Kramlinger and Post, 1996; Tillman and Geller, 2003). Short-lived states of mixed mood have been studied even less so (Swann et al., 2013). This gap in literature is important to fill given association of mixed symptoms with suicidality and severity of mood episodes (Swann et al., 2013).We used baseline data from an ongoing longitudinal study examining trajectories of cognitive and inflammatory response in individuals with bipolar disorder to study the prevalence, duration, and associations of subjectively reported mood states in which subjects rate themselves as feeling sad, happy, and energetic simultaneously. Our study design–which included self-reported affective ratings up to 3 times in a day–allowed us to explore the presence and duration of affective states on the scale of hours. Our sample included 50 participants with bipolar I and II disorder (BDs) and 91 healthy comparison participants (HCs). Bipolar disorder diagnosis was confirmed using the Structured Clinical Interview for DSM-IV. Inclusion criteria were diagnosis of Bipolar I or II disorder, age 25 years and greater, currently outpatient, and capable of providing informed consent. Exclusion criteria included acute illness or pregnancy, recent vaccination, history of dementia, seizures, Parkinson’s, stroke, or head trauma, history of cancer treatment, uncontrolled diabetes/hypertension, among others.