CHROMOGRANIN A CORRELATES WITH NOREPINEPHRINE RELEASE RATE
CHROMOGRANIN A CORRELATES WITH NOREPINEPHRINE RELEASE RATE
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DOI：
10.1016/0024-3205(92)90029-o
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发表时间：
1992-01-01
期刊：
影响因子：
6.1
通讯作者：
MILLS, P
中科院分区：
文献类型：
--
作者：
DIMSDALE, JE;OCONNOR, DT;MILLS, P
嗜铬粒蛋白A（CgA）是交感神经末梢和嗜铬细胞胞吐过程中与儿茶酚胺类物质共同释放的酸性蛋白质。先前的研究表明，交感神经系统（SNS）功能的大规模扰动导致CgA水平的相应变化 在 等离子体 小 是 已知 关于 CgA生理学意义我们假设，由于CgA和儿茶酚胺是从相同的储存囊泡中共同释放的，并且由于CgA不受再摄取或酶代谢的影响，血浆CgA应该反映了 去甲 释放 从 交感神经末梢。 我们 因此 测量 静脉 30例未用药受试者的CgA、去甲肾上腺素水平和去甲肾上腺素释放率。尽管CgA与血浆去甲肾上腺素的相关性很低（r = 0.37，p <0.05），但与去甲肾上腺素释放率的相关性却很高（r = 0.58，p <0.001）。因此，CgA可能为研究外周交感神经活动提供了一个新的视角。
Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Previous work has demonstrated that large scale perturbations in sympathetic nervous system (SNS) functioning result in corresponding changes in CgA levels in plasma. Little is known about the physiologic significance Of CgA. We hypothesized that, since CgA and catecholamines are co-released from the same storage vesicles, and since CgA is not subject to reuptake or enzymatic metabolism, plasma CgA should reflect norepinephrine release from sympathetic terminals. We therefore measured venous CgA, norepinephrine levels, and norepinephrine release rate in 30 unmedicated subjects. Although the correlation of CgA with plasma norepinephrine was only modest (r = 0.37, p < 0.05), its correlation with norepinephrine release rate was highly significant (r = 0.58, p < 0.001). Thus, CgA may offer a novel perspective on peripheral sympathetic activity.