Aminomethylations via cross-coupling of potassium organotrifluoroborates with aryl bromides
Aminomethylations via cross-coupling of potassium organotrifluoroborates with aryl bromides
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DOI：
10.1021/ol070543e
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发表时间：
2007-04-12
期刊：
影响因子：
5.2
通讯作者：
Sandrock, Deidre L.
中科院分区：
文献类型：
--
作者：
Molander, Gary A.;Sandrock, Deidre L.
[图形]N，N-二烷基氨基甲基三氟硼酸盐与芳基卤化物的Suzuki-Miyaura交叉偶联反应允许通过基于不协调反应模式的断开构建氨基甲基芳基连接。这些氨基甲基三氟硼酸盐底物的产率从高到高，然后显示出与富电子和贫电子芳基卤化物以及各种杂芳香溴化物具有相同的交叉偶联能力。
[GRAPHICS]The Suzuki-Miyaura cross-coupling reaction of N,N-dialkylaminomethyltrifluoroborates with aryl halides allows the construction of an aminomethyl aryl linkage through a disconnection based on dissonant reactivity patterns. A variety of these aminomethyltrifluoroborate substrates were prepared in good to excellent yields and then shown to cross-couple with equal facility to both electron-rich and electron-poor aryl halides as well as to a variety of heteroaromatic bromides.