Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise
Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise
复制标题
DOI：
10.1007/s00421-015-3252-3
复制
发表时间：
2015-12-01
影响因子：
3
通讯作者：
Peeling, Peter
中科院分区：
文献类型：
--
作者：
Badenhorst, Claire E.;Dawson, Brian;Peeling, Peter
目的研究24小时控制碳水化合物摄入对次日运动前后炎症反应和铁调素反应的影响（Ht 181.08 +/- 7.68 cm; Wt 74.8 +/- 11.5 kg，VO 2峰值68.9 +/- 7.2 ml kg（-1）min（-1））完成了两项实验（2天）试验。在第1天，参与者完成糖原消耗任务，包括16 km跑步（80% vVO（2 peak））和5 x 1 min努力（130% vVO（2 peak）），间隔2 min恢复。随后，在24 h内实施严格的饮食控制，其中提供低碳水化合物（LCHO 3 g kg（-1））或高碳水化合物（HCHO 10 g kg（-1））饮食。24小时后，参与者以85%vVO（2 peak）完成8 x 3 min间隔跑步，随后进行3 h监测恢复。分别在运动前、运动后即刻和运动后3 h采集静脉血，分析白细胞介素-6、血清铁、铁蛋白和铁调素。结果两组运动后即刻白细胞介素-6水平均较基线水平升高（p < 0.001），但HCHO组较低（p = 0.015）。HCHO中的铁调素水平在基线时也较低（p = 0.049），并且大的效应（d = 0.72）表明与LCHO相比，运动后3小时的铁调素水平有较低的趋势。两项试验（p = 0.001）运动后血清铁增加，而血清铁蛋白保持不变。结论24小时的控制低碳水化合物摄入导致更高的基线hepcidin水平和运动后IL-6反应比高碳水化合物摄入。这种激素的增加可能是由肝脏的促血管生成信号引起的，并且可能对运动员的铁代谢产生负面影响。
Purpose To examine the effects of 24-h controlled carbohydrate intake on next day pre-and post-exercise inflammatory and hepcidin responses.Methods In a crossover design, 12 well-trained endurance athletes (Ht 181.08 +/- 7.68 cm; Wt 74.8 +/- 11.5 kg, VO2peak 68.9 +/- 7.2 ml kg(-1) min(-1)) completed two experimental (2-day) trials. On day 1, participants completed a glycogen depletion task, including a 16-km run (80 % vVO(2peak)) and 5 x 1 min efforts (130 % vVO(2peak)) separated by 2-min recovery. Subsequently, strict dietary control was enforced for 24 h, where low carbohydrate (LCHO 3 g kg(-1)) or high carbohydrate (HCHO 10 g kg(-1)) diets were provided. Twenty-four hours later, participants completed an 8 x 3 min interval running session at 85 % vVO(2peak) followed by 3-h monitored recovery. Venous blood samples were collected pre-, immediately post-and 3-h post-exercise, which were analyzed for interleukin-6, serum iron, ferritin and hepcidin.Results Interleukin-6 was elevated (p < 0.001) immediately post-exercise compared to baseline in both conditions, but was lower in HCHO (p = 0.015). Hepcidin levels were also lower at baseline (p = 0.049) in HCHO, and a large effect (d = 0.72) indicated a trend for lower levels at 3-h post-exercise compared to LCHO. Serum iron was increased post-exercise for both trials (p = 0.001), whereas serum ferritin remained unchanged.Conclusions Twenty-four hours of controlled low carbohydrate intake resulted in higher baseline hepcidin levels and post-exercise IL-6 responses than a high carbohydrate intake. Such hormone increases may be induced by gluconeogenic signaling of the liver, and may negatively impact an athlete's iron metabolism.