Short Bowel Syndrome
Short Bowel Syndrome
复制标题
短肠综合症
DOI：
10.1007/978-3-319-27443-0_51
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
D. Mercer
中科院分区：
文献类型：
--
作者：
D. Mercer
短肠综合症是一种对儿童及其照顾者造成重大生活负担的诊断。它通常是由于大段小肠损失导致营养吸收不良所致。在最严重的肠衰竭中，患者依靠静脉营养来生存。历史上人们认为这只会导致毁灭性的结果。肠衰竭治疗的快速进展使大多数以前被认为无望的儿童的生存率显着提高，并实现了肠耐受性和 TPN 独立性的双重目标。最好在专门中心进行管理，儿童最初会得到全面的 TPN 支持，包括专门的脂质制剂。早期恢复肠道连续性和开始肠内喂养是标准做法。应监测儿童在推进肠内喂养和减少 TPN 支持方面的进展。如果此过程失败，应考虑手术干预和肠成形术。当肠道康复努力失败并且儿童出现危及生命的并发症时，应考虑进行肠道移植。强化的多学科治疗方法应该可以防止肠衰竭再次被视为无望的诊断。
Short bowel syndrome is a diagnosis that is a significant life burden for the child and his or her caregivers. It typically results from the loss of a large segment of the small intestine leading to malabsorption of nutrients. In the most severe form of intestinal failure, the patient is dependent on intravenous nutrition for survival. It was historically felt to lead only to a devastating outcome. Rapid advances in intestinal failure management have led to dramatic improvements in survival and to the achievement of the twin goals of enteral tolerance and TPN independence in most children formerly felt to be beyond hope. Best managed in specialized centers, children are initially given full TPN support including specialized lipid preparations. Early restoration of intestinal continuity and initiation of enteral feeds are standard. Children should be monitored for progress in advancing enteral feeds and reducing TPN support. If this process fails, consideration of operative intervention and enteroplasty should be made. When efforts at intestinal rehabilitation fail and children develop life-threatening complications, they should be considered for intestinal transplantation. An intensive multidisciplinary approach to management should prevent intestinal failure from ever again being considered a hopeless diagnosis.
影响因子：
9
作者：
Abu-Elmagd, Kareem M.;Costa, Guilherme;Mazariegos, George
通讯作者：
Mazariegos, George