Early life risk factors for obesity in childhood: cohort study
Early life risk factors for obesity in childhood: cohort study
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DOI：
10.1136/bmj.38470.670903.e0
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发表时间：
2005-06-11
影响因子：
105.7
通讯作者：
Sherriff, A
中科院分区：
文献类型：
--
作者：
Reilly, JJ;Armstrong, J;Sherriff, A
目的探讨英国早期(3岁以下)儿童肥胖的危险因素。设计前瞻性队列研究。对英国的8234名7岁儿童和909名儿童(重点关注的儿童)进行雅芳纵向研究，包括肥胖的其他早期生长相关危险因素。主要结果衡量7岁时肥胖，定义为体重指数和GT；结果在最终模型中，25个可能的危险因素中有8个与肥胖风险相关：父母肥胖(父母双方：调整后的优势比，10.44，95%可信区间5.11至21.32)，早年(43个月)体重指数或肥胖反弹(15.00，5.32至42.30)，3岁时每周看电视超过8小时(1.55，1.13至2.12)，追赶增长(2.60，1.09至6.16)，体重标准差分为8月龄(3.13，1.43~6.85)和18个月(2.65，1，25~5.59)；1岁时体重增加(1.06，1.02~1.10)；出生体重(1.05，1.03~1.07)；3岁时睡眠时间短(1.45，1.10~1.89)。结论早期8个因素与儿童肥胖风险增加有关。
Objective To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom.Design Prospective cohort study.Setting Avon longitudinal study of parents and children, United Kingdom.Participants 8234 children in cohort aged 7 years and a subsample of 909 children (children in focus) with data on additional early growth related risk factors for obesity.Main outcome measures Obesity at age 7 years, defined as a body mass index >= 95th centile relative to reference data for the UK population in 1990.Results Eight of 25 putative risk factors were associated with a risk of obesity in the final models: parental obesity (both parents: adjusted odds ratio, 10.44, 95% confidence interval 5.11 to 21.32), very early (by 43 months) body mass index or adiposity rebound (15.00, 5.32 to 42.30), more than eight hours spent watching television per week at age 3 years (1.55, 1.13 to 2.12), catch-up growth (2.60, 1.09 to 6.16), standard deviation score for weight at age 8 months (3.13, 1.43 to 6.85) and 18 months (2.65, 1, 25 to 5.59); weight gain in first year (1.06, 1.02 to 1.10 per 100 g increase); birth weight, per 100 g (1.05, 1.03 to 1.07); and short (< 10.5 hours) sleep duration at age 3 years (1.45, 1.10 to 1.89).Conclusion Eight factors in early life are associated with an increased risk of obesity in childhood.