FET-PET for malignant glioma treatment planning
FET-PET for malignant glioma treatment planning
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DOI：
10.1016/j.radonc.2011.03.001
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发表时间：
2011-04-01
影响因子：
5.7
通讯作者：
Belka, Claus
中科院分区：
文献类型：
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作者：
Niyazi, Maximilian;Geisler, Julia;Belka, Claus
背景和目的：本研究的目的是将基于MRI的形态学大体肿瘤体积（GTV）与生物学肿瘤体积（BTV）进行比较，生物学肿瘤体积（BTV）由使用F-18-氟乙基酪氨酸（FET）的正电子发射断层扫描（PET）成像中的病理放射性示踪剂摄取定义，随后是临床靶体积（CTV），最后是用于胶质母细胞瘤的放射治疗计划的计划靶体积（PTV）。17例胶质母细胞瘤患者被纳入回顾性方案。使用临床靶体积（CTV = BTV + 20 mm或CTV = GTV + 20 mm +包括水肿）和计划靶体积（PTV = CTV + 5 mm）进行治疗计划。使用OTP-Masterplan（R）进行图像融合和靶体积勾画。最初的大体肿瘤体积（GTV）定义仅基于MRI数据或仅基于FET-PET数据（BTV），其次两个数据集用于定义共同的CTV。结果：基于FET的BTV（中位数43.9 cm（3））大于相应的GTV（中位数34.1 cm（3），p = 0.028），17例中有11例GTV/BTV之间存在重大差异。为了评价两种计划方法的一致性，量化指数（CTVMRT boolean AND CTVFET）/（CTVMRT boolean OR CTVFET），其与1有显著差异（0.73 ± 0.03，p < 0.001）。基于FET-PET的靶点定义是否对治疗计划具有相关临床影响仍有待确定。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。放射治疗与肿瘤学99（2011）44-48
Background and purpose: The aim of this study was to compare MRI-based morphological gross tumour volumes (GTVs) to biological tumour volumes (BTVs), defined by the pathological radiotracer uptake in positron emission tomography (PET) imaging with F-18-fluoroethyltyrosine (FET), subsequently clinical target volumes (CTVs) and finally planning target volumes (PTVs) for radiotherapy planning of glioblastoma.Patients and methods: Seventeen patients with glioblastoma were included into a retrospective protocol. Treatment-planning was performed using clinical target volume (CTV = BTV + 20 mm or CTV = GTV + 20 mm + inclusion of the edema) and planning target volume (PTV = CTV + 5 mm). Image fusion and target volume delineation were performed with OTP-Masterplan (R). Initial gross tumour volume (GTV) definition was based on MRI data only or FET-PET data only (BTV), secondarily both data sets were used to define a common CTV.Results: FET based BTVs (median 43.9 cm(3)) were larger than corresponding GTVs (median 34.1 cm3, p = 0.028), in 11 of 17 cases there were major differences between GTV/BTV. To evaluate the conformity of both planning methods, the index (CTVMRT boolean AND CTVFET)/(CTVMRT boolean OR CTVFET) was quantified which was significantly different from 1 (0.73 +/- 0.03, p < 0.001).Conclusion: With FET-PET-CT planning, the size and geometrical location of GTVs/BTVs differed in a majority of patients. It remains open whether FET-PET-based target definition has a relevant clinical impact for treatment planning. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 99 (2011) 44-48