Papillary thyroid microcarcinoma: the significance of high risk features.
Papillary thyroid microcarcinoma: the significance of high risk features.
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DOI：
10.1186/s12885-017-3120-0
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发表时间：
2017-02-16
期刊：
影响因子：
3.8
通讯作者：
Wiseman SM
中科院分区：
文献类型：
--
作者：
Bradley NL;Wiseman SM
直径小于或等于1.0厘米的乳头状癌被诊断为甲状腺乳头状癌(PTM)。这些PTM的临床意义和治疗建议仍在发展中。本研究的目的是比较小(5 Mm)和大(≥5 mm)乳头状甲状腺微癌的特点。在同一中心接受甲状腺手术的1459例患者中，132例(9%)被诊断为PTM。我们使用Fisher‘s Exact Test对这些病例进行了回顾性分析。统计学意义先验设定为p <； 0.05。大的PTM与高危特征之间的关系仅在甲状腺外癌扩展(ETE)中观察到。57例大型PTM中有6例(11%)有ETE，而75例小型PTM中无一例发生ETE(p <； )。淋巴结转移与小PTM(5/9例)和大PTM(4/9例)有关。诊断为远处转移与小的PTM相关。对于PTM，无论是肿瘤体积小，还是缺乏高危特征，都不排除同步淋巴结转移的可能性。
Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thyroid microcarcinomas. Amongst 1459 sequential patients undergoing thyroid surgery at a single center, 132 (9%) cases were diagnosed with PTM. We performed a retrospective analysis of these cases using Fisher’s Exact Test. The statistical significance was set at p < 0.05 a priori. A relationship between large PTM and high risk features was observed only for extra-thyroidal cancer extension (ETE). Six of 57 large PTM (11%) but none of the 75 small PTM had ETE (p < 0.01). Lymph node metastases were associated with both small PTM (5/9 cases) and large PTM (4/9 cases). A distant metastases was diagnosed in association with a small PTM. For PTM, neither small cancer size, nor the absence of high-risk features, excluded the possibility of synchronous lymph node metastases.