Biomarkers of endometriosis
Biomarkers of endometriosis
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DOI：
10.1016/j.fertnstert.2013.01.097
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发表时间：
2013-03-01
影响因子：
6.7
通讯作者：
D'Hooghe, Thomas
中科院分区：
文献类型：
--
作者：
Fassbender, Amelie;Vodolazkaia, Alexandra;D'Hooghe, Thomas
子宫内膜异位症的非侵入性检查将有助于早期发现子宫内膜异位症的症状妇女谁有盆腔疼痛和/或不孕与正常的超声结果。这将包括几乎所有轻微至轻度子宫内膜异位症的病例，一些中重度子宫内膜异位症的病例，没有清晰可见的卵巢上皮瘤，以及盆腔粘连和/或其他盆腔病变的病例，这些病例可能会从手术中受益，以改善盆腔疼痛和/或生育能力低下。本综述讨论了子宫内膜异位症的非侵入性或半侵入性检测的诊断性能，包括已知的外周血生物标志物，蛋白质组学发现的蛋白质/肽标志物，miRNA和子宫内膜神经纤维密度。已经开发出具有高灵敏度和可接受特异性的检测方法;其中一些已在独立人群中得到验证，因此很有希望。为了取得真实的进展，需要在生物库开发方面达成国际协议，以制定组织样本收集、处理、储存和分析的标准操作程序，并对这些样本进行详细的临床表型分析。此外，有必要在一个独立的有症状的患者人群中前瞻性地验证任何有希望的测试的诊断准确性，这些患者患有生育力低下和/或疼痛，没有明确的子宫内膜异位症的超声证据，并且具有手术的临床指征，分为腹腔镜和组织学证实的子宫内膜异位症病例和腹腔镜证实不存在子宫内膜异位症的对照组。（Fertil Steril（R）2013; 99：1135 - 45. (C)美国生殖医学会（American Society for Reproductive Medicine）
A noninvasive test for endometriosis would be useful for the early detection of endometriosis in symptomatic women who have pelvic pain and/or subfertility with normal ultrasound results. This would include nearly all cases of minimal-to-mild endometriosis, some cases of moderate-to-severe endometriosis without a clearly visible ovarian endometrioma, and cases with pelvic adhesions and/or other pelvic pathology that might benefit from surgery to improve pelvic pain and/or subfertility. This overview discusses the diagnostic performance of noninvasive or semi-invasive tests for endometriosis, including panels of known peripheral blood biomarkers, protein/peptide markers discovered by proteomics, miRNA, and endometrial nerve fiber density. Tests with high sensitivity and acceptable specificity have been developed; some have been validated in independent populations and are therefore promising. To make real progress, international agreement on biobank development is needed for standard operating procedures for the collection, treatment, storage, and analysis of tissue samples and for detailed clinical phenotyping of these samples. Furthermore, it is necessary to validate the diagnostic accuracy of any promising test prospectively in an independent symptomatic patient population with subfertility and/or pain without clear ultrasound evidence of endometriosis and with a clinical indication for surgery, divided into cases with laparoscopically and histologically confirmed endometriosis and controls with laparoscopically confirmed absence of endometriosis. (Fertil Steril (R) 2013;99:1135-45. (C) 2013 by American Society for Reproductive Medicine.)