Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
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DOI：
10.1016/j.cell.2008.01.007
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发表时间：
2008-01-25
期刊：
影响因子：
64.5
通讯作者：
Guarente, Leonard
中科院分区：
文献类型：
--
作者：
Guarente, Leonard
最近对几种生物的热量限制的研究表明，线粒体活性的增加与这种饮食限制方案的有益效果有关。在这篇文章中，我推测线粒体活性的增加如何提供益处，并讨论饮食，线粒体和sirtuins如何在减缓衰老和相关疾病的途径中相互作用。
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.